Genetics Research
rs10848635
Gene: CACNA1C — Calcium Voltage-Gated Channel Subunit Alpha1 C
Chr 12:2207029
12p13.33
Intron Variant
Population Frequencies9
African
T 0.8226A 0.1774TT 0.687921TA/AT 0.269421AA 0.042658pop=4,454
African American
T 0.8212A 0.1788TT 0.686247TA/AT 0.26993AA 0.043823pop=4,290
African Others
T 0.86A 0.14TT 0.731707TA/AT 0.256098AA 0.012195pop=164
European
T 0.71966A 0.28034TT 0.560854TA/AT 0.317616AA 0.12153pop=11,240
Latin American 1
T 0.854A 0.146TT 0.746835TA/AT 0.21519AA 0.037975pop=158
Latin American 2
T 0.839A 0.161TT 0.727723TA/AT 0.222772AA 0.049505pop=404
Other
T 0.83A 0.17TT 0.728302TA/AT 0.203774AA 0.067925pop=530
South Asian
T 0.98A 0.02TT 0.952381TA/AT 0.047619AA 0pop=42
Studies27
Unread Studies27 ▼
1
Major Depressive Disorder (MDD) is a severe and debilitating disease affecting approximately 300 million people worldwide. Although several efforts have been made to develop …
2
QT prolongation is a heart rhythm condition that impacts the lives of many people and when severe can be life-threatening. QT prolongation has been linked to variations in several …
3
The identification of bipolar disorder (BD) type II patients has both treatment and prognostic implications. Better understanding of its underlying genetics may yield useful …
4
… Associations of rs10848635 with efficacy of the anti-depressant citalopram were also found [174]. The SNP rs4765913 was identified in two independent GWAS of European cohorts as …
5
Calcium voltage-gated channel auxiliary subunit β2 is a protein that, in humans, is encoded by the CACNB2 gene. The β2 subunit is an auxiliary protein of voltage-gated …
6
… Results involving CACNA1C SNPs (rs2283326, rs10848635, rs1006737) had contradictory direction of association across samples. ANK3 rs1049862 AA genotype showed a consistent …
7
本文重点从基因多态性角度综述了近些年有关钙离子通道与双相情感障碍关联性的研究, 并从认 知, 治疗, 预后等视角探讨了不同钙离子通道基因型对于双相障碍患者病情转归的影响. 同时探讨…
8
… Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and … Results : rs10848635 showed a significant association with schizophrenia (p=0.010), the …
9
… Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and … Results : rs10848635 showed a significant association with schizophrenia (p=0.010), the …
10
… CACNA1C rs1006737 and rs10848635 were the only polymorphisms that survived multiple-testing correction. In STAR*D the best pathway associated with TRD included CACNA1C (…
11
… rs10848635 and rs2283326 showed an effect on QTc in both original samples, but with no consistency in the direction of the effect. rs1006737 had a consistent effect in the two original …
12
To explore the associations between 24 single nucleotide polymorphisms (SNPs) within the CACNA1C gene and schizophrenia (SCZ) as well as antipsychotic treatment …
13
The present study aimed to explore whether 24 single nucleotide polymorphisms (SNPs) within the CACNA1C gene were associated with schizophrenia (SCZ) and antipsychotic …
14
Schizophrenia (SCZ) and bipolar disorder (BPD) are common, highly heritability psychiatric disorders. Genome-wide association studies have found evidence of shared genetic …
15
Associations of two voltage-gated calcium channel (Ca v ) genes, CACNA1C and CACNB2, were identified for bipolar disorder (BP) in different ethnic groups in recent …
16
Associations of two voltage-gated calcium channel (Ca v ) genes, CACNA1C and CACNB2, were identified for bipolar disorder (BP) in different ethnic groups in recent …
17
Recently, evidence has accumulated indicating that the MIR137 gene and the target gene CACNA1C of miR-137 might be two of the most robustly implicated genes in schizophrenia. In …
18
Autism is a pervasive developmental disorder typically characterized by repetitive behaviors, and deficits in social interaction and communication skills. Recent studies have linked …
19
… Dois polimorfismos no gene CACNA1C (rs10848635, rs1006737) tiveram um efeito protetor sobre episódios de TB. O polimorfismo rs1006737 também foi correlacionado com a …
20
… Two polymorphisms in the CACNA1C gene (rs10848635, rs1006737) had a protective effect on BD episodes. The polymorphism rs1006737 was also correlated with reduced severity …
21
… A dose response analysis of four markers (rs10848635, rs704326, rs11013860 and rs2284018) revealed high accumulative risk for increasing numbers of risk genotypes an individual …
22
… polymorphisms (SNPs)(rs10848635 and rs1006737) in the … The rs10848635 risk allele was significantly associated with … of citalopram-emergent suicidality (rs10848635: OR ¼ 1.29, …
23
Further evidence is required to confirm association between CACNA1C gene variants and bipolar affective di Page 1 Correspondence Psychological Medicine, 40 (…
24
Further evidence is required to confirm association between CACNA1C gene variants and bipolar affective di Page 1 Correspondence Psychological Medicine, 40 (…
25
There is significant unmet need for more effective treatments for bipolar disorder. The drug discovery process is becoming prohibitively expensive. Hence, biomarker clues to assist or …
26
… hypothesis testing) with treatment-emergent suicidality (rs10848635, P= .05, odds ratio=1.28; … These 2 SNPs also showed evidence of association with baseline agitation (rs10848635, P…
27
… en homocigotos con el alelo menor de rs10848635 en CACNA1C, así como el alelo …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
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