CHROMOSOME 11 DRD2 11q23.2 GENE VIEW DRD2 · 11q23.2 11q22 11q24 rs11214606 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs11214606 C / T · DRD2 · 11q23.2 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ C 5′ 3′ C HETEROZYGOUS 5′ 3′ C 5′ 3′ T HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ T 5′ 3′ T C Cytosine — reference allele T Thymine — variant allele genetics.jdge.cc

rs11214606

Gene: DRD2 — Dopamine Receptor D2 Chr 11:113439147 11q23.2 Intron Variant
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total C 0.952822T 0.047178CC 0.908031CT/TC 0.089582TT 0.002387pop=648,498
African C 0.99184T 0.00816CC 0.983756CT/TC 0.016165TT 0.000079pop=50,602
African American C 0.9916T 0.0084CC 0.983288CT/TC 0.01663TT 0.000082pop=48,826
African Others C 0.9983T 0.0017CC 0.996622CT/TC 0.003378TT 0pop=1,776
Asian C 0.99964T 0.00036CC 0.999283CT/TC 0.000717TT 0pop=13,950
East Asian C 0.9999T 0.0001CC 0.99981CT/TC 0.00019TT 0pop=10,510
European C 0.946348T 0.053652CC 0.895485CT/TC 0.101727TT 0.002788pop=530,850
Latin American 1 C 0.9717T 0.0283CC 0.94439CT/TC 0.054634TT 0.000976pop=6,150
Latin American 2 C 0.97754T 0.02246CC 0.955715CT/TC 0.043645TT 0.000639pop=12,510
Other C 0.96456T 0.03544CC 0.930327CT/TC 0.068466TT 0.001206pop=26,524
Other Asian C 0.9988T 0.0012CC 0.997674CT/TC 0.002326TT 0pop=3,440
South Asian C 0.962T 0.038CC 0.926188CT/TC 0.071537TT 0.002275pop=7,912

Studies12

Unread Studies12
1
Mental illness represents a major health issue both at the individual and at the socioeconomical level. This is partly due to the current suboptimal treatment options: existing …
2
Motivated by applications in genomics, we consider in this paper global and multiple testing for the comparisons of two high-dimensional linear regression models. A procedure for …
3
This study addresses the underlying genetic components of addiction, specifically that which relates to nicotine use, abuse, and dependence. One of the problems with genetic research …
4
Schizophrenia is a debilitating disease affecting approximately 70 million people worldwide. Response to treatment, much like the disorder itself, is highly heritable, …
5
Genomewide association studies (GWASs) on antidepressant efficacy have yielded modest results. A possible reason is that response is influenced by other factors, which …
6
This review considers pharmacogenetics of the so called ‘second-generation‘ antipsychotics. Findings for polymorphisms replicating in more than one study are emphasized and …
7
Examine the unique and congruent findings between multiple raters in a genomewide association studies (GWAS) in the context of understanding individual differences in …
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To examine the unique and congruent findings between multiple raters in a genome-wide association study (GWAS) in the context of understanding individual differences in …
9
In 1990, Blum and colleagues first reported an association between DRD2 and alcoholism. While there have been subsequent replications of this genetic association, there have also …
10
Many people frequently tan indoors despite being aware of the increased risk of melanoma. Ultraviolet radiation is hypothesized to modify biological reward pathways, for example, …
11
Alcohol consumption and problems are complex human behaviors that are influenced by both genetic and environmental risk factors (Kendler et al., 1992; Kendler et al., 1994). One …
12
… The top finding in this analysis was rs11214606 at DRD2, mediating the effects of olanzapine on working memory (p-value=4.84 × 10 −7 , q-value=0.022). This is the same SNP at …
Curated Studies0

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0

No unused studies.