Genetics Research
rs11254363
Population Frequencies12
African
A 0.69559G 0.30441AA 0.484645AG/GA 0.421893GG 0.093462pop=58,612
African American
A 0.69551G 0.30449AA 0.484674AG/GA 0.421675GG 0.093651pop=56,636
African Others
A 0.6979G 0.3021AA 0.483806AG/GA 0.428138GG 0.088057pop=1,976
Asian
A 0.96926G 0.03074AA 0.940059AG/GA 0.058396GG 0.001545pop=12,946
East Asian
A 0.979G 0.021AA 0.958254AG/GA 0.041534GG 0.000212pop=9,438
European
A 0.743708G 0.256292AA 0.554422AG/GA 0.378572GG 0.067006pop=438,020
Latin American 1
A 0.7089G 0.2911AA 0.50445AG/GA 0.408949GG 0.086601pop=8,314
Latin American 2
A 0.80993G 0.19007AA 0.655009AG/GA 0.309836GG 0.035155pop=10,980
Other
A 0.75958G 0.24042AA 0.585233AG/GA 0.348703GG 0.066064pop=26,762
Other Asian
A 0.943G 0.057AA 0.891106AG/GA 0.103763GG 0.005131pop=3,508
South Asian
A 0.703G 0.297AA 0.502583AG/GA 0.400892GG 0.096524pop=8,516
Studies30
Unread Studies30 ▼
1
Single-nucleotide polymorphism (SNP) allele frequencies, dietary habits, and folate status and their associations vary across ethnic populations. Little is known about the …
2
… Finally, the polymorphisms which have been mostly associated with vitamin B12 concentration are the rs11254363 polymorphism at intron 52 of the intrinsic factor vitamin B12 receptor …
3
Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of …
4
Diabetes mellitus is the commonest endocrinopathy, Worldwide. Inspite of its commonality, the genetic basis of etiopathogenesis and pathophysiology are ever evolving …
5
The pandemic caused by the new coronavirus has caused shock waves in many countries, producing a global health crisis worldwide. Lack of knowledge of the biological mechanisms …
6
Aberrancies in fetal DNA methylation programming may modify disease susceptibility of the offspring. Maternal folate status has potential to alter fetal DNA methylation. …
7
… In various independent studies on healthy individuals the CUBN rs1801222, rs4748353, rs11254363, rs12243895 variants were either associated with a higher vitamin B12 status or a …
8
… SNP’s rs11254363 and rs526934 are mapped in genes CUBN and transcobalamin, respectively, and are involved in the absorption and transport of vitamin B12. Similarly, in a study …
9
We review the role of disorders of one-carbon metabolism (OCM) in the etiopathogenesis of schizophrenia, define directions for further research into the role of single nucleotide genetic …
10
Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors…
11
The very old (aged 85 and over) are the fastest growing age group in the UK and most western societies. High incidence of disability and chronic diseases, financial constraints, …
12
… (GWAS) study showed the rs11254363 A>G in the intron of CUBN is related to increasing VB12 levels [18]; and we have previously found that the rs11254363 G allele of CUBN …
13
… Rs153734 for folate and rs11254363 for vitamin B12 did not reach GWAS significance (P-… Sensitivity analysis excluding rs11254363 for vitamin B12 gave a similar estimate (OR 0.95, 95…
14
… The rs11254363 variant of the cubilin-encoding gene (CUBN) reduces the risk of CHD by increasing the level of circulating vitamin B 12 , which plays the key role in the folate-…
15
… Other SNPs may be associated with the level of vitamin B-12 include rs11254363 and rs526934, located in intron 52 of the intrinsic factor-cobalamin receptor, cubilin (CUBN [MIM …
16
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency, but this test has substantial false positive and false …
17
… Considering that the rs1801222 wild-type C allele had higher vitamin B12 levels (data of the correlation between rs11254363 was not shown in the GWAS studies) 27, the haplotype …
18
Among Canadian women of reproductive age, 5% and 20% have serum vitamin B-12 concentrations indicative of deficiency (<148 pmol/L) and marginal status (148–220 …
19
Genetic variation can cause variable responses to environmental stimuli. A number of single-nucleotide polymorphisms (SNPs) have been associated with B vitamin status …
20
Autoimmune gastritis may present as pernicious anaemia arising from vitamin B 12 malabsorption, but also with iron deficiency anaemia due to iron malabsorption. These …
21
This study determined maternal and cord blood concentrations of vitamin B12, choline and their metabolites as well as their association with maternal diet and fetal genetic variants. …
22
… We investigated the genotypic association between rs11254363 and CHD in 4 genetic models: co-dominant, dominant, recessive and over-dominant. In both cohorts, the most …
23
… These two SNPs were rs11254363 on the ‘intrinsic factor-cobalamin’ receptor cubilin gene (CUBN; MIM: 602997 ) and rs526934 on the transcobalamin I gene (TCN1; MIM: 189905 ) [2]. …
24
… five remained significant in multiple regression analysis: rs719235 (GGH), rs9606756 (TCN2), rs41301825 (AHCY), and rs492602 (FUT2) in the genetic additive model and rs11254363 …
25
Vitamin B12 (VitB12 or cobalamin) is an essential cofactor in several metabolic pathways. Clinically, VitB12 deficiency is associated with pernicious anemia, neurodegenerative disorder…
26
… five remained significant in multiple regression analysis: rs719235 (GGH), rs9606756 (TCN2), rs41301825 (AHCY), and rs492602 (FUT2) in the genetic additive model and rs11254363 …
27
Low plasma B-vitamin levels and elevated homocysteine have been associated with cancer, cardiovascular disease and neurodegenerative disorders. Common variants in FUT2 on …
28
… These were rs11254363 in intron 52 of the intrinsic factor—cobalamin receptor, cubilin (… There is evidence for heterogeneity among studies for rs11254363 (χ 2 = 9.24, p = 0.03) but not …
29
… These were rs11254363 in intron 52 of the intrinsic factor—cobalamin receptor, cubilin (CUBN [MIM 602997]) … There is evidence for heterogeneity among studies for rs11254363 (c2 …
30
[spa] Las vitaminas son una parte esencial de nuestra dieta. Presentar carencias o excesos en los niveles de estas puede ser perjudicial para la salud. Los desequilibrios en los …
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