Genetics Research
rs1150226
Population Frequencies12
African
A 0.3172G 0.6828AA 0.10206AG/GA 0.430289GG 0.467651pop=55,242
African American
A 0.31518G 0.68482AA 0.100206AG/GA 0.429949GG 0.469844pop=53,290
African Others
A 0.3724G 0.6276AA 0.152664AG/GA 0.439549GG 0.407787pop=1,952
Asian
A 0.0024G 0.9976AA 0AG/GA 0.00474GG 0.99526pop=9,704
East Asian
A 0.0003G 0.9997AA 0AG/GA 0.000515GG 0.999485pop=7,772
European
A 0.08077G 0.91923AA 0.006784AG/GA 0.147972GG 0.845244pop=406,846
Latin American 1
A 0.1276G 0.8724AA 0.015563AG/GA 0.224158GG 0.760279pop=8,610
Latin American 2
A 0.0679G 0.9321AA 0.005326AG/GA 0.125157GG 0.869518pop=12,768
Other
A 0.09765G 0.90235AA 0.013927AG/GA 0.16744GG 0.818633pop=12,494
Other Asian
A 0.0109G 0.9891AA 0AG/GA 0.021739GG 0.978261pop=1,932
South Asian
A 0.0483G 0.9517AA 0.001301AG/GA 0.093984GG 0.904715pop=6,150
Studies45
Unread Studies45 ▼
1
… Moreover, we found that motives for substance use were correlated with single nucleotide polymorphisms SNPs rs1923882 and rs1150226, with the latter SNP also being associated …
2
… В результате генотипирования были выявлены значимые ассоциации для полиморфных вариантов: rs1150226 ( HTR3A ), rs3828942 ( LEP ), rs2069514 ( CYP1A2 ), rs7185735 …
3
Alcohol use disorder (AUD) is among the leading causes of morbidity and mortality worldwide, and over 95 million people live with alcohol dependence globally. The …
4
… Three genetic polymorphisms that enhance 5-HT3 receptor complex function (rs1150226-AG or rs1150226-GG and rs1176713-GG) were associated with enhanced ondansetron AUD …
5
… Combined, the effect of the rs1761942-AC and rs1150226-AG genotypes may further enhance the time the receptor ion channel is opened. Even though the 5-HT3B subunits do not …
6
… The rs1150226AG variant of the 5HT3A receptor is associated with an increase in the time … Combined, the rs1761942-AC and rs1150226-AG would be expected to further enhance the …
7
A core principle in the pursuit of scientific knowledge is that science is self-correcting and that important results should be replicable. Hypotheses need to be reinforced, adjusted, or …
8
Submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the School of La Trobe Rural Health School, La Trobe University, Victoria, Australia. …
9
Зависимость от психоактивных веществ (ПАВ) является распространенным психическим расстройством, которое ложится тяжелым бременем на непосредственно …
10
This chapter reviews the results of pharmacogenetic studies in the management of addictive disorders. A large body of research indicates the advantages with respect to prediction of …
11
… with only one of these two genotypes as nonresponders, unless they were carriers for one or more of the remaining three markers tested in the EA genotype panel (ie, rs1150226:AG …
12
… in the 3′untranslated region of the SLC6A4 gene that encodes the serotonin transporter and/or one, two, or three of the SNPs on the genes for the 5HT3 receptor subunits: rs1150226-…
13
… SNPs rs1042173, rs1176713 and rs1150226 were explored as predictors of response. Participants had a mean age of 44.9 ± 9.4 years, were mostly men (60.0%), and African American …
14
Cocaine use disorder (CUD) has significant consequences and there remain no FDA-approved pharmacotherapies. Ondansetron is an indirect dopaminergic modulator …
15
Alcohol remains one of the most commonly used substances in the world, with a pronounced presence across the globe and a significant and varied cultural history. A National Survey …
16
… Furthermore, a secondary analysis of the above-described study [Citation140] found that individuals with allelic variation in the HTR3A (rs1150226-AG and rs1176713-GG) and …
17
… and AG and GG polymorphisms in the rs1150226 and rs1176713 portions of the HTR3A gene, … However, it is important to keep in mind that the potential functionality of rs1150226 and …
18
Genetics of alcohol addiction is currently a contradictive and complex field, where data in the most studies reflect methods’ limitations rather than meaningful and complementary results. …
19
… G), and the HTR3A (rs17614942 and rs1150226) and HTR3B (rs17614942) genes. Notably, a human laboratory study also supports the interaction of ondansetron with the SLC6A4 …
20
В обзоре рассматриваются результаты фармакогенетических исследований в наркологии. Показано, что система фармакогенетических маркеров может быть использована …
21
Neuronal activity triggers the rapid expression of immediate early genes that play important roles in experience-driven synaptic changes, learning, and memory. While …
22
Alcohol use disorder (AUD) is a complex psychiatric condition characterized by craving, compulsive seeking, loss of control of alcohol consumption as well as the …
23
Variants in serotonergic genes are implicated in nicotine dependence (ND) in subjects of European and African origin, but their involvement with smoking in Asians is largely unknown. …
24
… revealed that individuals with one or more of the following genotypes, rs1150226-AG and rs1176713-GG in HTR3A, or rs17614942AC in HTR3B, had significantly greater …
25
For more than 25 years, researchers have made advances in developing medications to treat alcohol use disorder (AUD), highlighted by the US Food and Drug Administration’s (FDA’s) …
26
Pharmacogenetic studies of alcohol use disorder (AUD) have suggested that the efficacy of treatments for AUD is, in part, influenced by the genetic …
27
Genetic factors contribute to more than 50% of the variation in the vulnerability to alcohol dependence (AD). Although significant advances have been made in medications for AD, these …
28
Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual, 5th Edition (DSM–5), is a heterogeneous disorder stemming from a complex interaction of …
29
SLC6A4, the gene encoding the serotonin transporter protein (5-HTT), has been extensively examined as a risk factor for alcohol dependence (AD). More recently, variability in the …
30
… = 1.6) while SNPs rs897687 and rs1150226 showed protective effect of the minor alleles (G … ); ‘protection’ (at least one of the rs897687 G and the rs1150226 T alleles); ‘mixed’ (at least a …
31
Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of …
32
… The specific HTR3A and HTR3B predictive genotypes identified in this study were rs1150226–AG, rs1176713–GG and rs17614942–AC, respectively. When all individuals carrying any …
33
… The authors reported that patients carrying one or more of the genotypes rs1150226-AG or rs1176713-GG (in HTR 3A ), rs17614942-AC (in HTR 3B ) or rs1042173-TT (in SLC6A4) is …
34
… the 2 polymorphisms in SLC6A4, response to ondansetron treatment was also significantly greater than for placebo in individuals with 1 or more of the following genotypes: rs1150226-…
35
… For patients carrying one or more of the genotypes rs1150226-AG and rs1176713-GG in HTR3A and rs17614942-AC in HTR3B, a mean difference in drinks per drinking day (2.5), …
36
The purpose of this exploratory study was to examine the interaction of 5-HTTLPR and DRD4 exon III polymorphisms with gender in non-treatment seeking alcohol-dependent (AD) …
37
… that we detected with SNPs rs1150226 and rs17614942 were … of the functionality of rs1150226 and rs1176713 of HTR3A and … The rs1150226 is located in the promoter region of HTR3A …
38
To compare the publication and citation rate within the areas of drug abuse and dependence research in Europe with that in the USA. Methods. This is a bibliometric study …
39
… Results showed that individuals possessing one or more genotypes for rs1150226-AG and rs1176713-GG in the HTR3A gene and rs1714942-AC in HTR3B exhibited a reduction of two …
40
An overview of a number of research papers examines application of pharmacogenetic tests in narcology. It has been proven that a system of pharmacogenetic tests can be used for the …
41
Methylphenidate (MPH)-Ritalin®, a psychostimulant that blocks reuptake of synaptically released norepinephrine and dopamine in the brain, is used clinically …
42
Current Genome-Wide Association Studies (GWAS) have successfully detected many genetic variants contributing to common diseases but not rare ones. Here two haplotype-based …
43
… We also found that SNP rs1150226 in HTR3A was significantly associated with the PSC in the temporal area. All remaining genes showed no significant association in either area, and …
44
We employed physiogenomic analyses to investigate the relationship between myalgia and selected polymorphisms in serotonergic genes, based on their involvement with pain …
45
The present study focused on 91 single-nucleotide polymorphisms (SNPs) in 21 candidate genes to find associations with major depressive disorder (MDD). In total, 160 healthy …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.