Genetics Research
rs11568668
Glycine 487 → Valine
Gene: ABCC4 — ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)
Chr 13:95186786
13q32.1
Missense Variant
Population Frequencies6
Asian
C 0.99608T 0.00392CC 0.992349CT/TC 0.007464TT 0.000187pop=10,718
East Asian
C 0.9957T 0.0043CC 0.991451CT/TC 0.008549TT 0pop=8,656
European
C 0.999997T 0.000003CC 0.999994CT/TC 0.000006TT 0pop=331,684
Other
C 0.9999T 0.0001CC 0.999762CT/TC 0.000238TT 0pop=8,416
Other Asian
C 0.9976T 0.0024CC 0.99612CT/TC 0.00291TT 0.00097pop=2,062
Studies11
Unread Studies11 ▼
1
The use of tyrosine kinase inhibitors (TKIs) has become the mainstay of treatment in patients suffering from chronic myeloid leukemia (CML), an adult leukemia caused by a reciprocal …
2
… -endoperoxide synthase 1 (PTGS1) (rs3842787 and rs10306114); PTGFR (rs3753380 and rs3766355); multidrug resistance protein 4 (MRP4) (rs11568658 and rs11568668). The …
3
Plasma efavirenz (EFV) concentrations within therapeutic levels are essential to successfully treat patients suffering from human immunodeficiency virus (HIV) type 1. In …
4
Numerous studies have reported the emergence of antimicrobial resistance during the treatment of common infections. Multidrug resistance (MDR) leads to failure of antimicrobial …
5
Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due …
6
Broad-spectrum resistance in cancer cells is often caused by the overexpression of ABC transporters; which varies across individuals because of genetic single-nucleotide …
7
Broad inter-individual variation exists in susceptibility to arsenic-induced tumours, likely involving differences in the ability of individuals to eliminate this metalloid. We recently identified …
8
… This project focused on the G487E MRP4 variant (rs11568668) found in the SOPHIE project at a 0.008 allele frequency (n = 120) amongst Asian American individuals [38]. The G487E …
9
The purpose of this study is to evaluate the association between variants in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin F (2α) receptor (PTGFR), and …
10
目的探讨人核苷转运蛋白1 (hCNT1/SLC28A1) 及多药耐药蛋白4 (MRP4/ABCC4) 基因多态性 与治疗乙型肝炎核苷类似物药物恩替卡韦(ETV) 及替比夫定(LdT) 治疗慢性乙型肝炎的病毒学…
11
ABCC4 encodes multidrug resistance protein 4 (MRP4), a member of the ATP-binding cassette family of membrane transporters involved in the efflux of endogenous and xenobiotic …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.