Genetics Research
rs13306278
Population Frequencies11
African
C 0.9723T 0.0277CC 0.944584CT/TC 0.055416TT 0pop=5,558
African American
C 0.9712T 0.0288CC 0.94243CT/TC 0.05757TT 0pop=5,350
Asian
C 0.982T 0.018CC 0.964912CT/TC 0.035088TT 0pop=114
East Asian
C 0.99T 0.01CC 0.977273CT/TC 0.022727TT 0pop=88
European
C 0.85661T 0.14339CC 0.733668CT/TC 0.245881TT 0.020451pop=17,114
Latin American 1
C 0.89T 0.11CC 0.798246CT/TC 0.184211TT 0.017544pop=228
Latin American 2
C 0.933T 0.067CC 0.870324CT/TC 0.124688TT 0.004988pop=802
Other
C 0.897T 0.103CC 0.798226CT/TC 0.197339TT 0.004435pop=902
Other Asian
C 0.96T 0.04CC 0.923077CT/TC 0.076923TT 0pop=26
South Asian
C 0.833T 0.167CC 0.705882CT/TC 0.254902TT 0.039216pop=102
Studies28
Unread Studies28 ▼
1
… Notably, the COMT variant rs13306278 was linked to increased quetiapine exposure. CYP3A5 and CYP2B6 phenotypes also affected quetiapine variability, with the ATP-binding …
2
Ramipril is an angiotensin‐converting enzyme inhibitor used for hypertension and heart failure management. To date, scarce literature is available on pharmacogenetic associations …
3
Statins are the primary drugs used to prevent cardiovascular disease by inhibiting the HMG-CoA reductase, an enzyme crucial for the synthesis of LDL cholesterol in the liver. A …
4
Fesoterodine is one of the most widely used antimuscarinic drugs to treat an overactive bladder. Fesoterodine is extensively hydrolyzed by esterases to 5-hydroxymethyl …
5
Many pharmacological treatments are considered effective in the treatment of panic disorder (PD), however, about 20 to 40% of the patients have treatment-resistant PD. …
6
… C-peptide concentrations were significantly higher after aripiprazole treatment compared to its initial levels, and COMT polymorphisms rs4680 G/G and rs13306278 T influenced these …
7
… However, a recent study suggests that a portion of quetiapine may be metabolized by this enzyme [5]; in the latter work, the COMT rs13306278 T led to the accumulation of a metabolite (…
8
In recent times, the progress of Clinical Pharmacogenetics has been remarkable. Its implementation in the United States and Europe is gradually increasing. At the regulatory level, …
9
Cocaine is a stimulant that with repeated use creates an addiction that can be characterized by alterations in the brain's reward circuitry and a compulsion in seeking and taking of the …
10
Donepezil and memantine are the most common drugs used for Alzheimer’s disease. Their low effectiveness could partly be explained by genetic factors. Thus, we aim to identify Single …
11
Η επιστήμη της κλινικής φαρμακολογίας και της φαρμακοθεραπευτικής αποτελεί βασικό πυλώνα της ιατρικής καθώς έχει σημειώσει αξιοσημείωτη πρόοδο στην ανάπτυξη θεραπειών …
12
… COMT rs13306278 and rs4680 polymorphisms were merged into a haplotype: carrying no mutant allele was assigned as wild-type, carrying one mutant allele was considered as …
13
… C-peptide concentrations were higher after aripiprazole administration and were influenced by catechol-O-methyltransferase (COMT) rs4680 and rs13306278 polymorphisms. …
14
… The COMT rs13306278 T allele was significantly related to … Assuming that COMT rs13306278 causes a decrease in COMT … of volunteers heterozygous for COMT rs13306278 (n = 3) …
15
The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, …
16
… Las concentración de péptido C fueron más altas después de la administración de aripiprazol y fueron influenciadas por los polimorfismos COMT rs4680 y rs13306278. La olanzapina …
17
… The disequilibrium for ABCB1 rs4728709 and COMT rs13306278 could be explained by the small sample size. Regarding the CYP2D6 and CYP3A4 polymorphisms it is explained by …
18
… C-peptide concentrations were higher after aripiprazole administration and were influenced by COMT rs4680 and rs13306278 polymorphisms. Olanzapine and the UGT1A1 rs887829 …
19
… 3) Apart from COMT rs4680, other variants like the COMT rs737865, rs2020917 and rs13306278 polymorphisms can be also studied and are considered to be strongly related to …
20
Major depressive disorder is a common, serious and in some cases, life‐threatening condition and affects approximately 350 million people globally. Although there is effective …
21
Schizophrenia (SZ) and bipolar disorder (BD) are severe mental diseases associated with cognitive impairment, mood disturbance, and psychosis. Both disorders are highly heritable …
22
… Furthermore, they reported that rs13306278 is … SNP rs13306278 and rs2075507 (P2 SNP). Ji and colleagues also performed an electromobility shift assay and showed that rs13306278 …
23
Catechol-compounds such as 4-hydroxy-estrogen have been shown to play a role in the renal carcinogenesis process. To counter the effects of the highly reactive and mutagenic …
24
… терапию [46], кроме того, данный полиморфизм связан со скоростью реализации антидепрессивного действия пароксетина и флувоксамина [47], а полиморфизм rs13306278 …
25
Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes …
26
… However, the observed association of SNP rs13306278 with remission in the Mayo study … large studies, the minor allele at SNP rs13306278 was associated with lower rates of remission …
27
… They identified one specific SNP, rs13306278, that had a significant association with remission in Caucasian, non-Hispanic subjects. Furthermore, another study examined the role of …
28
… COMT rs13306278 and rs4680 polymorphisms were merged into a haplotype: carrying no mutant allele was assigned as wild-type, carrying one mutant allele was considered as …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.