Genetics Research
rs17288723
Population Frequencies12
African
T 0.97131C 0.02869TT 0.943692TC/CT 0.055245CC 0.001063pop=50,792
African American
T 0.97036C 0.02964TT 0.941813TC/CT 0.057083CC 0.001103pop=48,946
African Others
T 0.9967C 0.0033TT 0.993499TC/CT 0.006501CC 0pop=1,846
Asian
T 0.9948C 0.0052TT 0.989646TC/CT 0.010354CC 0pop=9,658
East Asian
T 0.9987C 0.0013TT 0.997419TC/CT 0.002581CC 0pop=7,750
European
T 0.848458C 0.151542TT 0.720131TC/CT 0.256655CC 0.023215pop=404,746
Latin American 1
T 0.8953C 0.1047TT 0.80258TC/CT 0.185441CC 0.011979pop=8,682
Latin American 2
T 0.92547C 0.07453TT 0.857619TC/CT 0.135708CC 0.006672pop=16,786
Other
T 0.89773C 0.10227TT 0.807605TC/CT 0.180259CC 0.012136pop=12,360
Other Asian
T 0.979C 0.021TT 0.958071TC/CT 0.041929CC 0pop=1,908
South Asian
T 0.9281C 0.0719TT 0.862069TC/CT 0.132075CC 0.005856pop=6,148
Studies37
Unread Studies37 ▼
1
Over the past two decades, suicide has consistently ranked among the leading causes of death in the United States. While suicide deaths are closely associated with uicidal ideation …
2
Обзор литературы посвящён анализу связи суицидального поведения как с генными локусами, так и установленными полиморфизмами генов. Рассмотрена связь с …
3
Обзор литературы посвящён анализу связи суицидального поведения как с генными локусами, так и установленными полиморфизмами генов. Рассмотрена связь с …
4
… rs17288723 374-х пациентов с тяжѐлой депрессией после 4-х недельного лечения [49]. Аналогичный результат для полиморфизмов HTR2A гена получен и при метаанализе …
5
Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major …
6
Neuropsychological assessment is often viewed as separate from suicide risk assessment. However, significant evidence suggests elevated risk of suicide among populations with …
7
Alzheimer’s disease (AD) is a neurodegenerative disorder accounting for 60–70% of dementia cases. Genetic origin accounts for 49–79% of disease risk. This paper aims …
8
The overview outlines two decades of research from the European Group for the Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …
9
One-third of depressed patients develop treatment-resistant depression with the related sequelae in terms of poor functionality and worse prognosis. Solid evidence …
10
Fluoxetine is an effective and well-tolerated pharmacological treatment for children and adolescents with major depressive disorder (MDD). However, a high percentage of …
11
Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study …
12
An initial pharmacogenetic study of the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) clinical trial reported an association between genetic variation in …
13
It has been difficult to identify genes affecting drug response to Selective Serotonin Reuptake Inhibitors (SSRIs). We used multiple cross-sectional assessments of depressive symptoms …
14
A depressao refrataria e caracterizada por ciclos recorrentes de longa duracao de episodios severos, que nao remitem ao utilizar varios tipos de antidepressivos. Ate 20% desses …
15
Despite the common use of antidepressant drugs for the treatment of various psychiatric illnesses, selection of initial antidepressant therapy and subsequent drug modification strategies …
16
… between the A-1438G (rs6311) polymorphism and mood disorders have been obtained [80], and several studies have found associations between the rs7997012 and rs17288723 …
17
Pharmacogenomics and the search for personalized medicine focus on the attainment of individualized pharmacotherapies that cover genetic variation and target groups of patients that …
18
In pharmacogenomics studies, gene-gene interactions play an important role in characterizing a trait that involves complex pharmacokinetic and pharmacodynamic mechanisms, …
19
To summarize current concepts on neuroendocrine and genetic principles underlying stress-related depression and to discuss the challenges of personalized treatment in …
20
Die Gruppe der Antidepressiva ist hinsichtlich ihrer chemischen Strukturen heterogen, dennoch ist ihnen eine Beeinflussung der monoaminergen Transmission gemeinsam. In welcher …
21
Klengel T, Heck A, Pfister H, Brückl T, Hennings JM, Menke A, Czamara D, Müller‐Myhsok B, Ising M. Somatization in major depression ‐ clinical features and genetic associations. …
22
Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence …
23
… For two SNPs in intron 2 of HTR2A, rs17288723 and rs2770297, we observed nominally significant genotypic associations with remission but not response after 5 weeks in the unipolar (…
24
… locations, and additional HTR2A SNPs identified as functional pharmacogenomic candidates, including the promoter variant rs6311 and intronic variants rs7997012 and rs17288723. …
25
As part of a convergent functional genomics (CFG) strategy, expanding upon our earlier work [Le-Niculescu et al., 2009b], we set out to comprehensively identify candidate genes for …
26
We previously proposed and provided proof of principle for the use of a complementary approach, Convergent Functional Genomics (CFG), combining gene expression and genetic …
27
While our data do not provide a direct replication of the STAR* D results, the number of positive associations within these genes with remission in our sample support the …
28
Due to marked circadian disturbances observed among bipolar disorder (BD) patients, several studies have analyzed a possible link with genes involved in the molecular …
29
Due to marked circadian disturbances observed among bipolar disorder (BD) patients, several studies have analyzed a possible link with genes involved in the molecular …
30
Due to marked circadian disturbances observed among bipolar disorder (BD) patients, several studies have analyzed a possible link with genes involved in the molecular …
31
While our data do not provide a direct replication of the STAR* D results, the number of positive associations within these genes with remission in our sample support the …
32
… and rs1360780 in FKBP5, a gene associated with treatment response in STAR*D and MARS, as well a their interaction terms, the best model included the main effects for rs17288723 …
33
While our data do not provide a direct replication of the STAR* D results, the number of positive associations within these genes with remission in our sample support the …
34
… We obtained the best results for rs10892608 in GRIK4 and rs17288723 in 5-HTR2A. … Rs17288723 in HTR2A was genotypically associated with remission after 5 weeks (empirical p = …
35
While our data do not provide a direct replication of the STAR* D results, the number of positive associations within these genes with remission in our sample support the …
36
While our data do not provide a direct replication of the STAR* D results, the number of positive associations within these genes with remission in our sample support the …
37
The aim of this study was to investigate the association between the T102C polymorphism on the 5HT2A gene and cognitive function as well as clinical manifestations in patients with …
Curated Studies0 ▼
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Unused Studies0 ▼
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