Genetics Research
rs2030323
Population Frequencies12
African
A 0.06554C 0.93446AA 0.004369AC/CA 0.122339CC 0.873292pop=39,366
African American
A 0.06677C 0.93323AA 0.004495AC/CA 0.124544CC 0.870961pop=37,818
African Others
A 0.0355C 0.9645AA 0.001292AC/CA 0.068475CC 0.930233pop=1,548
Asian
A 0.42517C 0.57483AA 0.183616AC/CA 0.483113CC 0.333271pop=10,718
East Asian
A 0.4314C 0.5686AA 0.18394AC/CA 0.494865CC 0.321195pop=8,568
European
A 0.217628C 0.782372AA 0.047424AC/CA 0.340409CC 0.612167pop=370,572
Latin American 1
A 0.1747C 0.8253AA 0.027611AC/CA 0.294118CC 0.678271pop=3,332
Latin American 2
A 0.1693C 0.8307AA 0.024893AC/CA 0.288911CC 0.686196pop=7,954
Other
A 0.22854C 0.77146AA 0.057116AC/CA 0.342853CC 0.600031pop=12,886
Other Asian
A 0.4005C 0.5995AA 0.182326AC/CA 0.436279CC 0.381395pop=2,150
South Asian
A 0.2699C 0.7301AA 0.0849AC/CA 0.370058CC 0.545042pop=3,086
Studies68
Unread Studies68 ▼
1
The incidence of obesity has significantly increased worldwide. However, it is still unclear about the genetic susceptibility of obesity. Methods Here we performed the largest …
2
Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in …
3
… V rs2030323 byla zaznamenána statistická významnost rozdílu ve skóre svědomitosti u genotypu GG. Kvůli těmto zjištěním autoři přisuzují svědomitosti určitou důležitost pro bojové …
4
Metabolic disorders and neurocognitive diseases frequently co-occur, yet the specific mechanisms driving this comorbidity remain elusive. While epidemiological …
5
Сложность патогенеза бронхиальной астмы (БА) обусловлена влиянием факторов окружающей среды, генетических и эпигенетических факторов, взаимодействующих …
6
… in the distribution of BDNF rs2030323 genotypes. The rs2030323 genotype distribution in the … difference between groups in the frequency of rs2030323 alleles. The allele distribution in …
7
Osteoarthritis is the most prevalent joint disorder, and osteoarthritis associated with high BMI contributes significantly to the global disease burden. The aim of this study is …
8
В представленном исследовании в популяционной выборке якутов изучена изменчивость частот аллелей однонуклеотидных полиморфизмов, ассоциированных с ИМТ и …
9
Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy with potential long-term health implications for the mother and child. The interplay …
10
This systematic review aims to assess the genetic determinants influencing combat sports performance and address potential gaps in previous reviews. Twenty-four selected studies …
11
Some studies and societal discussions have suggested a potential link between overweight and a higher risk of mental disorders and suicidal ideation. However, the causal …
12
This narrative review examines the relationship between dopamine-related genetic polymorphisms, personality traits, and athletic success. Advances in sports genetics have identified …
13
To investigate the causal relationship between obesity and meniscal injuries using Mendelian randomization (MR). Genetic loci independently associated with obesity and meniscal …
14
Diet modulates the genetic risk of obesity, but the modulation has been rarely studied using genetic risk scores (GRSs) in children. Our objectives were to identify single nucleotide …
15
It is reported that overweight may lead to accelerated aging. However, there is still a lack of evidence on the causal effect of overweight and aging. We collected genetic variants …
16
儿童肥胖是全球性的公共健康问题, 不仅危害儿童自身健康, 还是成年期慢性病发病的重要诱因 . 近年来, 随着精准医学研究的深入开展, 越来越多的研究证据指明环境, 行为因素, 如早期宫内…
17
To investigate the causal relationship between obesity and spinal stenosis using Mendelian randomisation (MR). Methods Genetic loci independently associated with obesity …
18
Essential hypertension in paediatric patients and young adults is rising, mostly on account of obesity-related hypertension. Clinically, the difference between obese hypertensive and …
19
Obesity is defined as excess body fat accumulated in the adipose tissue when the individual reaches BMI values equal to or greater than 30 kg/m 2 . It is one of the main risk factors for …
20
In the era of the fourth industrial revolution technology, the inclusion of personalized nutrition for healthcare (PNH), when establishing a healthcare platform to prevent chronic diseases …
21
A obesidade é definida pelo excesso de gordura corporal acumulada no tecido adiposo quando o indivíduo atinge valores de IMC igual ou superior a 30 Kg/m2. Constitui um dos …
22
La cirugía bariátrica (CB) consigue efectos sustanciales y persistentes en la pérdida de peso en pacientes con obesidad mórbida (OM) y mejora el tratamiento de las comorbilidades …
23
The scarcity of the results obtained for the treatment of obesity leads us to consider new strategies, contemplating all the factors involved in the development of the disease. One of the …
24
As BDNF is one of the group of neurotrophins highly influencing the processes happening in the brain, such as the processes of learning and personality creation, we decided to look …
25
Childhood obesity has increased worldwide, and many clinical and public interventions have attempted to reduce morbidities. However, there are no reliable biomarkers to …
26
We evaluated the effect of the genetic variant rs10767664 of BDNF gene on anthropometric and biochemical changes after weight loss secondary to a high-fat hypocaloric …
27
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
28
Obesity has become a serious problem because of its constant growth and numerous metabolic complications. Overweight and obesity are defined as excessive body fat accumulation …
29
The addition of genetic factors to prognostic models of neurobehavioral recovery following pediatric traumatic brain injury (TBI) may account for unexplained heterogeneity in outcomes. …
30
Brain‐derived neurotrophic factor (BDNF) is an important growth factor that supports neurodevelopment and plasticity, particularly in brain regions involved in learning and memory. The …
31
The prevalence of obesity and the associated comorbidities highlight the importance of understanding the regulation of energy homeostasis. The central melanocortin system plays a …
32
The contains results for the top 10,000 variants in an MTAG analysis for male puberty. The data on both age at voice breaking and timing of facial hair have been used in generating this …
33
… identified brain-expressed obesity-related loci, namely FTO-rs1558902, MC4R-rs2331841, MAP2K5-rs4776970, GNPDA2-rs16858082, PCSK1-rs261967, and BDNF-rs2030323, …
34
Obesity is one of the main risk factor for the development of socially important diseases, determining the life quality and human longevity. According to the World Health Organization (…
35
Ожирение является одной из глобальных проблем здравоохранения, приводящих к существенному экономическому и социальному ущербу как в развитых, так и в …
36
Obesity is one of the global health problems resulting in significant economic and social damage in both developed and developing countries. Overweight and obesity are key risk …
37
Stroke leads to long term sensory, motor and cognitive impairments. Most patients experience some degree of spontaneous recovery which is mostly incomplete and varying greatly …
38
… demonstrated with the strength of independent replication that another genetic variant of the BDNF gene (rs2030323) was associated with 100–150 greater total calorie intake per …
39
A better understanding of the genetic underpinning of total energy, carbohydrate, and fat intake is a prerequisite to develop personalized dietary recommendations. For this purpose, we …
40
Heart failure is a complex disease, which is presented differently by men and women. Several studies have shown that reproductive factors, such as age at natural menopause, parity …
41
… rs2030323 … rs2030323 …
42
Genome-wide association studies have identified multiple variants associated with adult obesity, mostly in European-ancestry populations. We aimed to systematically assess the …
43
… Among non-Hispanic white participants, the association of BDNF rs2030323 with total caloric intake was stronger (β=− 151.99, SE= 30.09; p<. 0001), and association of FTO rs1421085 …
44
Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In …
45
Obesity is emerging as a global health problem, with more than one-third of the world’s adult population being overweight or obese. In this study, we investigated worldwide …
46
Septic shock is a leading cause of death in intensive care units. Septic shock occurs when a body-wide infection leads to low blood pressure, and ultimately organ failure. Some recent …
47
The brain derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in the cell survival, axonal and dendritic growth, and synaptic plasticity. BDNF gene …
48
… Ras-associated protein Rap1; rs11165643 polypyrimidine tract-binding protein 2; rs1421085 fat mass and obesity-associated protein; rs7127684 ribosomal protein L27a; rs2030323 …
49
In high-, middle- and low-income countries, the rising prevalence of obesity is the underlying cause of numerous health complications and increased mortality. Being a complex and …
50
精 神 疾 患 は 脳 の 機能 障 害 に 伴 い, 精神 及 び 行 動 の 障 害を 呈 す る 症 状 および疾 患 の 総 称 で あ る. 精 神 科 受 診 数の多 い 精 神 疾 患 に うつ 病, 統 合 失 調症お よび 双 極 性 障 害 …
51
… II promoter binding site, and that the rs2030323 could disrupt the pattern of recognition; this implied a possible negative effect of rs2030323 on BDNF gene transcription (Zhang et al., …
52
Personality traits are complex phenotypes influenced by interactions of multiple genetic variants of small effect and environmental factors. It has been suggested that the brain derived …
53
To examine the association between the polymorphisms of brain-derived neurotrophic factor (BDNF) gene with heroin dependence. Methods: Genomic DNA was isolated …
54
Obesity is a major public health concern. This condition results from a constant and complex interplay between predisposing genes and environmental stimuli. Current attempts to …
55
The MORGAM cohort (Monitoring of trends and determinants in Cardiovascular disease, Risk, Genetics, Archiving and Monograph) is a consortium of cohort studies, whose data have …
56
Depression is a well-established risk factor for cardiac morbidity and mortality in patients with coronary artery disease (CAD). Previous studies have demonstrated that the level of brain-…
57
Obesity is a major health problem around the globe. The statistics of overweight and obesity at early ages have reached alarming levels and placed our country in the fi rst place in …
58
Obesity is a highly heritable trait. While acute and chronic changes in body weight or obesity-related comorbidities are heavily influenced by environmental factors, there are still strong …
59
Antecedentes Actualmente en México casi ocho de cada 10 adultos cursan con sobrepeso u obesidad acompañado de un estado inflamatorio crónico. La Encuesta Nacional de Salud …
60
Genome-wide association studies (GWAS) of obesity-related traits are defining the genetic architecture of obesity, revealing genes and mechanisms for disease. GWAS have been …
61
… Among the seven SNPs associated with increased BMI, two (rs2030323 and rs10767664) localize to the intron (intron 3) upstream of exon 4, one (rs6265) in the coding region, and four …
62
La obesidad es uno de los principales problemas de salud pública a nivel mundial. Es una enfermedad crónica, compleja y de origen multifactorial que se caracteriza por el exceso de …
63
Obesity is one of the major public health problems worldwide. It is a chronic, complex, and multifactorial-origin disease characterised by body fat excess mainly due to an imbalance …
64
Anorexia nervosa (AN) is an eating disorder (ED) with substantial morbidity and the highest mortality among psychiatric disorders. Low body mass index (BMI) is the sine qua non of AN, …
65
Diabet. Med. 29, e62–e66 (2012) Abstract Aims Despite rapid advancements and many new diabetes susceptibility loci found in the past few years, few genetic variants associated with …
66
… Rs2030323 was not further analyzed because it could not be genotyped successfully with the genotyping platform in the study. The genotype distributions of the remaining three SNPs …
67
SNP Minor allele Major allele MAF HWE P-value GWAS P-value Ref rs1000940 GA 0.32 0.70 1.3 x10-08 1 rs10132280 AC 0.29 0.22 1.1 x10-11 1 rs1016287 TC 0.26 1.00 2.3 x10-11 1 …
68
The prevalence of obesity has risen dramatically in the last decades and its comorbidities, such as metabolic syndrome (MetS) and cardiovascular disease, are the major cause of …
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