Genetics Research
rs2072660
Gene: CHRNB2 — Cholinergic Receptor Nicotinic Beta 2 Subunit
Chr 1:154576245
1q21.3
Non Coding Transcript Variant
Population Frequencies12
African
T 0.43938C 0.56062TT 0.199048TC/CT 0.480663CC 0.320289pop=43,698
African American
T 0.43806C 0.56194TT 0.197702TC/CT 0.480724CC 0.321574pop=42,124
African Others
T 0.4746C 0.5254TT 0.23507TC/CT 0.479034CC 0.285896pop=1,574
Asian
T 0.2527C 0.7473TT 0.062482TC/CT 0.380438CC 0.55708pop=6,850
East Asian
T 0.2506C 0.7494TT 0.061506TC/CT 0.378226CC 0.560269pop=5,658
European
T 0.2327C 0.7673TT 0.054696TC/CT 0.356006CC 0.589297pop=323,202
Latin American 1
T 0.3068C 0.6932TT 0.097561TC/CT 0.418428CC 0.484011pop=7,380
Latin American 2
T 0.22563C 0.77437TT 0.053162TC/CT 0.344932CC 0.601906pop=14,484
Other
T 0.27568C 0.72432TT 0.087918TC/CT 0.375529CC 0.536553pop=10,396
Other Asian
T 0.2626C 0.7374TT 0.067114TC/CT 0.39094CC 0.541946pop=1,192
South Asian
T 0.189C 0.811TT 0.03252TC/CT 0.313008CC 0.654472pop=492
Studies41
Unread Studies41 ▼
1
Patients with hypertension are recommended to decrease their salt intake. However, some patients do not follow this recommendation. It is possible that some of these individuals …
2
… For CHRNB2, the T allele of the rs2072660 polymorphism (MAF = 0.23) has previously been linked to altered risk for nicotine dependence [39], and the T allele of the rs4292956 (MAF = …
3
Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in 2 Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the …
4
Changes in high-affinity nicotinic acetylcholine receptors are connected to cognitive impairment in Alzheimer’s Disease (AD). The nicotinic α5 subunit (coded by CHRNA5) is …
5
Genome-wide Association Studies (GWAS) give special insight into genetic differences and environmental influences that are part of different human disorders and provide prognostic …
6
This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for …
7
Delayed recovery from general anesthesia is a well-known complication that requires predictive tools and approaches. This study aimed to determine significant factors associated …
8
… CHRNB2 gén polimorfizmusainak és a dohányos fenotípus kapcsolatának vizsgálata során az FTND tekintetében magasabb pontszámot mértünk az rs2072660 TT genotípussal …
9
Nicotine dependence is influenced by genetic, individual, and psychological factors. We aimed to examine whether nicotinic acetylcholine receptor genes (…
10
A dohányzás vezető oka az idő előtti mortalitásnak, a megelőzhető morbiditásnak és a rokkantságnak világszerte. Csak a nem fejlett országokban több mint 1 milliárd embert érint a …
11
Samoubilačko ponašanje predstavlja globalni zdravstveni problem s obzirom da oko milion ljudi godišnje izvrši samoubistvo, a efikasne mere prevencije ili lečenja ne postoje. Kao i …
12
Genetic studies have revealed a significant association between variants in nicotinic acetylcholine receptor (CHRN) genes and smoking cessation, but the …
13
… One SNP, the rs2072660 in 3′ UTR, had a significant effect on the FTND score (p = 0.010). … However, in interaction with ALC, rs2072660 was significantly associated with ZSDS-S (p = …
14
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disorder characterized by debilitating fatigue accompanied by pain and impairments in memory, cognition, …
15
… The most significant tetragenic interaction model was rs1013402–rs1044394–rs2072660–… The black square represents the interaction, rs1013402–rs1044394–rs2072660–rs6559840…
16
Numerous single nucleotide polymorphisms (SNPs) in multiple nicotinic receptor genes (CHRN) are associated with smoking. However few studies have examined the association …
17
… The GEE-GMDR method detected the most significant tetragenic interaction model (rs2072660- rs1209068- rs11030134- rs6011770) with an empirical p value of 2.62e-04 and test …
18
Health interventions aimed at smoking cessation have significant public health impacts, yet they are often linked to weight gain. This cohort study evaluated weight changes in patients …
19
Impairments in various aspects of language, including the manipulation and comprehension of verbal and written language, are common in pediatric populations. Some disorders of …
20
Genetic influences on smoking cessation treatment outcome may be affected by pretreatment patient characteristics. Nicotine dependence is arguably the most salient …
21
Tobacco-related behaviors and the underlying addiction to nicotine are complex tangles of genetic and environmental factors. Efforts to understand the genetic component of these traits …
22
… Two highly correlated SNPs in the 3′ UTR region rs2072660/rs2072661 have been … We attempted to genotype rs2072660 in this study, but the error rate in our sample was 1.3%…
23
Objectifs: Plusieurs polymorphismes nucléaires localisés sur les gènes des récepteurs nicotiniques cholinergiques CHRN sont associés au tabagisme. Cependant, peu d’…
24
We are interested in developing integrative approaches for variable selection problems that incorporate external knowledge on a set of predictors of interest. In particular, we have …
25
… with west African ancestry are without the rs2072660 nausea-reducing genotypes observed in … reported a relation between one of the CHRNB2 SNPs examined here (rs2072660) and …
26
Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a major independent risk factor for lung cancer. Genome-wide association (GWA) …
27
Components of the brain reward system, ie the mesolimbic dopamine, laterodorsal cholinergic and ghrelin signaling systems, have been implicated in alcohol reward in preclinical …
28
… In the present study, we did not test nicotine dependence or failure to quit, and also did not find an association with rs2072660 which shows modest LD with rs2072661. However, other …
29
Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of …
30
… Die Genotypisierung dreier SNPs (single strand nucleotide polymorphism, rs2072659, rs2072660, rs2072661), welche nahe letzterer liegen, ergab einen gemeinsamen Haplotyp. …
31
… testing with common SNPs with adjustment for correlated tests within each gene identified a significant association with two CHRNB2 SNPs, eg, the minor allele of rs2072660 increased …
32
A genetic predisposition to febrile seizures (FS) has long been recognized. The inheritance appears to be polygenic in small families or sporadic cases of FS encountered in …
33
The neuronal nicotinic receptor genes (CHRN) have been implicated in a variety of smoking‐related behaviors. Here we tested for association between an early subjective response …
34
35
Co-occurring alcohol and nicotine dependence is common, as is alcohol use disorder and overeating. However, major risk genes for these disorders need to be identified. Certain …
36
… allele for rs2072661 and rs2072660 (haplotypes 11001011 … rs2072660 are driving the effect in this region. We further confirmed the independent effect of either r2072661 or rs2072660 …
37
Certain mutations in specific parts of the neuronal nicotinic acetylcholine receptor (nAChR) subunit genes CHRNA4, CHRNB2, and probably CHRNA2, can cause autosomal dominant …
38
Nicotine addiction and alcohol dependence are highly comorbid disorders that are likely to share overlapping genetic components. We have examined two neuronal nicotinic receptor …
39
Cholinergic dysfunction has been proposed for the pathogenesis of bipolar disorder (BD), and we have therefore performed a systematic association study of cholinergic system genes …
40
… found that rs2072660, which had been examined in other studies with negative results, and its haplotypes had a nominally significant protective effect against smoking initiation. SNPs …
41
Assume we have a dataset that consists of both families and unrelated individuals. For the purpose of illustrating the outline of our method, we use nuclear families only, but its …
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