Genetics Research
rs2224721
Population Frequencies12
African
T 0.40189G 0.59811TT 0.158611TG/GT 0.486564GG 0.354824pop=45,104
African American
T 0.40103G 0.59897TT 0.157476TG/GT 0.487099GG 0.355425pop=43,486
African Others
T 0.4252G 0.5748TT 0.189122TG/GT 0.472188GG 0.33869pop=1,618
Asian
T 0.3938G 0.6062TT 0.157213TG/GT 0.473078GG 0.369709pop=6,946
East Asian
T 0.3972G 0.6028TT 0.157821TG/GT 0.478701GG 0.363478pop=5,728
European
T 0.215428G 0.784572TT 0.047051TG/GT 0.336752GG 0.616196pop=327,386
Latin American 1
T 0.3065G 0.6935TT 0.092291TG/GT 0.428381GG 0.479328pop=7,498
Latin American 2
T 0.36472G 0.63528TT 0.135885TG/GT 0.457661GG 0.406454pop=14,998
Other
T 0.28859G 0.71141TT 0.085616TG/GT 0.40595GG 0.508435pop=11,026
Other Asian
T 0.3777G 0.6223TT 0.154351TG/GT 0.446634GG 0.399015pop=1,218
South Asian
T 0.377G 0.623TT 0.146758TG/GT 0.460751GG 0.392491pop=586
Studies45
Unread Studies45 ▼
1
No reliable biomarkers currently exist to aid in identification of effective treatments for individuals experiencing depression. Dysregulation of the hypothalamic-pituitary-adrenal stress …
2
Antidepressant medications are frequently used as the first line of treatment for depression. However, their effectiveness is highly variable and influenced by genetic factors. Recently, …
3
L’étiologie des comportements antisociaux est complexe et varierait au cours de la vie. Tandis que les études antérieures suggèrent que de nombreux facteurs de …
4
Tardive dyskinesia (TD) is a common side effect of antipsychotic treatment. This movement disorder consists of orofacial and limb-truncal components. The present study is …
5
… For example, for the HTR2A, different markers (rs2224721 and rs9316233) in the same region of the gene (intron 2) as rs7997072 were nominally significantly associated with response …
6
Защита состоится «____» _________ 2023 года в ___. ___ часов на заседании диссертационного совета 24.1. 215.03 на базе Федерального государственного бюджетного …
7
Despite prevalent binge drinking and alcohol-dependent symptoms among Hispanics, few studies have examined how multidimensional factors influence Hispanic …
8
Heritability of antisocial behaviour is estimated at approximately 50% and involves multiple genes.AimsTo investigate the cumulative genetic effects of 116 single nucleotide …
9
Schizophrenia (SCZ) is a common and severe mental disorder. Genetic factors likely play a role in its pathophysiology as well as in treatment response. In the present study, we …
10
Mood disorders are common and disabling disorders. Despite the availability of over 100 psychotropic compounds, only one-third of patients benefit from first-line treatments…
11
Одним из распространенных и серьезных побочных эффектов нейролептиков является гиперпролактинемия, которая существенно снижает качество жизни пациентов и в …
12
Definition of response is critical when seeking to establish valid predictors of treatment success. However, response at the end of study or endpoint only provides one view …
13
The contraction of the genioglossus muscle is realized by the binding of serotonin with serotonin 2A receptor through modulating the hypoglossal motor output. When the …
14
Personalized therapeutics is the emerging field in the medicine based on the individual’s unique characteristics like genetic profile/alterations, epigenetic modifications, clinical …
15
Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and …
16
Тема данной магистерской диссертации «Ассоциация полиморфных вариантов генов дофаминовых и серотониновых рецепторов с развитием гиперпролактинемии у …
17
Major depressive disorder is the most common psychiatric disorder, worldwide, yet response and remission rates are still unsatisfactory. The identification of genetic …
18
… gene and found that two common variants (rs2224721 and rs1923886) and a haplotype block (… association between these two common variants (rs2224721 and rs1923886) near the 5’…
19
The reason why it is difficult to identify susceptibility genes attributed to bipolar disorder (BPD) is the phenotypic heterogeneity. The use of endophenotypes has been …
20
… In another study, other HTR2A SNPs (rs9316233 and rs2224721) but not rs7997012 were among the best predictors of escitalopram response Citation[64]. Another positive finding …
21
There is considerable variation in the individualized response to psychotropic drug therapies, which include antidepressants, antipsychotics and mood stabilizers. It has been proposed …
22
Severe mental disorders, such as Major Depressive Disorder (MDD), Bipolar Disorder (BD) and Schizophrenia (SCZ), represent a huge burden to society, reflecting the limited efficacy …
23
Genetic variations in the serotoninergic system contribute to body-mass index in Chinese adolescents
Obesity has become a worldwide health problem in the past decades. Human and animal studies have implicated serotonin in appetite regulation, and behavior genetic …
24
… Rs2224721 harbored by the same gene was associated with the risk of bipolar disorder 19 and was one of the two best predictors of escitalopram response in the GENDEP (Genome-…
25
… could not confirm the rs7997012 SNP in the genome-based therapeutic drugs for depression sample; however, they found several other SNPs (rs9316233, rs7324218 and rs2224721) …
26
… phism 21438G4A (rs6311) in the regulatory region of the HTR2A gene and alteration in food intake [91,92,93,94], but the significant SNP rs2224721 we found is intronic. Recent studies …
27
… for smoking and COMT) ranged from 2.3%—for the relationship of HTR2A [5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled] single-nucleotide polymorphisms rs2224721 …
28
Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic burden, both for the high prevalence of the disorder and the unsatisfying response rate of the …
29
… , GENDEP, investigating patients treated with the antidepressants escitalopram and nortriptyline, found associations between two HTR2A polymorphisms (rs9316233 and rs2224721) …
30
… Instead, two intronic markers in the HTR2A gene (rs931623 and rs2224721, which are in linkage disequilibrium) were both significantly associated with response to the SSRI. Therefore, …
31
… In the GENDEP sample (N=760), the markers rs9316233, rs2224721 and rs7324218 showed a significant association with treatment response [128]. It has been noted that patients …
32
While for other complex disorders like cancer a limited number of markers are at hand, there are currently no biomarkers available for major depression. A major goal is therefore the …
33
Personalized medicine — the adaptation of therapies based on an individual’s genetic and molecular profile — is one of the most promising aspects of modern medicine. The …
34
Growing evidence suggests that pro-inflammatory cytokines play a major role in the complex pathophysiology of major depressive disorder (Capuron and Dantzer 2003, Irwin and Miller …
35
… [66] reported that rs7324218, rs9316233 and rs2224721 were associated with response to AD pharmacotreatment. Serotonin-6 receptor (5-HT6) is a G-protein coupled receptor which …
36
Response and remission defined by cut-off values on the last observed depression severity score are commonly used as outcome criteria in clinical trials, but ignore the …
37
… result was association with SNP rs2224721 in intron 2 of the … with the intronic SNP rs2224721 cannot be compared with … these tests, with rs2224721 remaining significant (empirical P …
38
… The top three of the 116 hypothesized associations (rs9316233, rs2224721 and rs852977) were attributed a q-value of 0.106. Thus, taking into account the number of comparisons …
39
Bipolar affective disorder is a severe mood disorder, which is characterised by episodes of mania and depression. The aetiology of bipolar disorder remains elusive, with little known …
40
(論文の内容の要旨)[背景] 閉塞性睡眠時無呼吸症候群 (Osas) はその発症機序において後天的 な原因である環境的要素だけではなく遺伝的要素が示唆されている. 遺伝的要因としては顎顔面の…
41
Актуальность. Тардивная дискинезия (ТД)–это тяжелое и потенциально необратимое двигательное расстройство, которое может развиваться как побочный эффект …
42
Введение. Депрессия как полифакторное, гетерогенное заболевание предопределяется не только неблагоприятными средовыми факторами, но и воздействием многих генов…
43
Актуальность. В гериатрической практике бессонница является распространенной формой нарушений сна, возникающей у 75‒80% пожилых людей. Порядка 75‒90% …
44
Шизофрения является одним из наиболее сложных психических заболеваний, поскольку характеризуется целым спектром психических нарушений, сочетанием позитивной и …
45
267 stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant (リポカリン 2 は変異型 CD44 の発現亢進を介して卵巣明細胞癌細胞の鉄関連…
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
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