Genetics Research
rs2276302
Population Frequencies12
African
G 0.51237A 0.48763GG 0.26466GA/AG 0.495417AA 0.239923pop=49,966
African American
G 0.51073A 0.48927GG 0.263116GA/AG 0.495227AA 0.241657pop=48,184
African Others
G 0.5567A 0.4433GG 0.306397GA/AG 0.500561AA 0.193042pop=1,782
Asian
G 0.1447A 0.8553GG 0.024541GA/AG 0.240256AA 0.735203pop=9,698
East Asian
G 0.1393A 0.8607GG 0.021375GA/AG 0.2359AA 0.742725pop=7,766
European
G 0.309881A 0.690119GG 0.096498GA/AG 0.426767AA 0.476736pop=401,128
Latin American 1
G 0.3273A 0.6727GG 0.109145GA/AG 0.436351AA 0.454504pop=8,704
Latin American 2
G 0.2318A 0.7682GG 0.05547GA/AG 0.352655AA 0.591876pop=16,838
Other
G 0.31136A 0.68864GG 0.104983GA/AG 0.412765AA 0.482253pop=12,002
Other Asian
G 0.1661A 0.8339GG 0.037267GA/AG 0.257764AA 0.704969pop=1,932
South Asian
G 0.2166A 0.7834GG 0.056966GA/AG 0.319336AA 0.623698pop=6,144
Studies47
Unread Studies47 ▼
1
Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). This study conducted a meta-analysis of current research of the …
2
… AG genotypes at the rs2276302 locus demonstrated superior … In the aforementioned study, the rs1062613 and rs2276302 … the AA genotype at rs2276302 and rs1062613 showed better …
3
Despite the proven clozapine effectiveness in patients with treatment resistant schizophrenia, its use can cause adverse drug reactions, including clozapine-induced …
4
ВВЕДЕНИЕ. Клозапин эффективен при лечении пациентов с терапевтической резистентностью при шизофрении, но его применение может сопровождаться развитием …
5
… The second study reported an association between the T allele of HTR3A rs106263 and the G allele of HTR3A rs2276302 with the clozapine response after patients were stable on …
6
Treatment-resistant schizophrenia (TRS) is often associated with severe burden of disease, poor quality of life and functional impairment. Clozapine is the gold standard for the …
7
… Consistent with this, this study also discovered that minor alleles of both rs1062613 and rs2276302 were closely linked with clozapine responses. What is innovative about this study is …
8
… T allele of rs106263 and the G allele of rs2276302 were associated with a good response to … allele of rs106263 and the G allele of rs2276302 correlate with good response to treatment […
9
… izvijestili su da polimorfizam rs2276302 i rs1062613 HTR3A pokazuju značajne genotipske asocijacije s odgovorom na klozapinsko liječenje, nalaz koji su potvrdili Rajkumar i sur. (…
10
Тема данной магистерской диссертации «Роль вариантов полиморфных генов рецепторов дофамина, серотонина и мелатонина в развитии метаболического синдрома при …
11
In this paper, a total of 20 sites of single nucleotide polymorphisms (SNPs) on the serotonin 3 receptor A gene (HTR3A) and B gene (HTR3B) are used for feature fusion with age, …
12
Zusammenfassung Mittels einer Assoziationsstudie wurde untersucht, ob die individuelle Neurotizismusausprägung durch Einzelnukleotidpolymorphismen (engl.: single nucleotid …
13
… Two SNPs in HTR3A, the upstream variant rs1150226 and intronic variant rs2276302, were … Two of the SNPs in the haplotype, rs1150226 and rs2276302, were found associated with …
14
Актуальность. Встречаемость резистентной к терапии шизофрении оценивается в диапазоне 20–40% и остается без динамики в последнее десятилетие. Известно, что …
15
Random effects two-part models have been applied to longitudinal studies for zero-inflated (or semi-continuous) data, characterized by a large portion of zero values and continuous non…
16
Although genetics contributes significantly to smoking addiction, the susceptibility genes and variants underlying it remain largely unknown. Many years of genome-wide and candidate …
17
Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to …
18
… of rs1062613 and rs2276302 in the HTR3A gene with the clozapine response, demonstrating that the T allele of rs106263 and the G allele of rs2276302 were associated with a good …
19
Studies related to pharmacogenomics have considerably increased in recent years in India. The interests shown by our researchers are largely reflecting the global trend towards the …
20
… In fact, rs1062613 and rs2276302 explain only 13.8% of the variability in the responses to clozapine, while clinical predictors combined with a HTR3A pharmacogenetic association …
21
In this article, we will review the recent progress in pharmacogenetics of antipsychotic drugs in regard to treatment response in schizophrenia. Recent Findings …
22
Single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B have been reported to be associated with bipolar disorder in European and Japanese populations. We explored the …
23
The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, …
24
The effects of single‐nucleotide polymorphisms ( SNP s) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but …
25
Identification of patient subgroups to enhance treatment effects is an important topic in personalized (or tailored) alcohol treatment. Recently, several recursive partitioning …
26
Previous studies have implicated genes encoding the 5-HT3 AB receptors (HTR3A and HTR3B) and the serotonin transporter (SLC6A4), both independently and interactively, in alcohol …
27
… treatment response for 3 alleles on 5HT3A, rs2276302-rs1062613-rs1150226; however, … , and the 5HTR3A polymorphisms rs1062613 and rs2276302 in 101 patients with treatment-…
28
To improve antipsychotic treatment in schizophrenia patients, many studies have investigated genetic polymorphisms associated with antipsychotic metabolizing enzymes …
29
Interpatient variability in clinical response to antipsychotics (AP) is observed in the treatment of schizophrenia (SCZ) with evidence to support a genetic basis for this phenomenon. …
30
Pharmacologic studies implicate a significant role of genes encoding the serotonin transporter (SLC6A4) and the 5-HT 3AB subunits HTR3A and HTR3B in nicotine …
31
Cocaine dependence is a neuropsychiatric disorder in which both environmental and genetic factors are involved. Several processes, that include reward and neuroadaptations, …
32
… Our data for rs2276302 genotypes were complete. However, repeated PCR of one sample failed to amplify the HTR3A gene region flanking rs1062613, probably due to other …
33
This study examined whether the choice of pain-related outcome to represent opioid efficacy influenced findings in a genetic association study. Data from the European …
34
The serotonin type 3 (5‐HT 3 ) receptor (R) belongs to the family of ligand‐gated ion channels. It is supposed to play an important role in the pathogenesis of schizophrenia and might …
35
Suicide is a major contributor to the morbidity and mortality of schizophrenia, accounting for approximately 10% of deaths in these patients. Genetic factors have been reported to …
36
Cancer pain patients need variable opioid doses. Preclinical and clinical studies suggest that opioid efficacy is related to genetic variability. However, the studies have small samples, …
37
… There was one haplotype block extending from rs897692 to rs2276302 that included eight haplotypes with ⩾0.01 frequency that accounted for 0.97 of the haplotype diversity. Of these, …
38
Problem gambling is the subclinical form of pathological gambling and both are characterized by difficulties in the limiting of money and time spent on gambling. Genetic and personality …
39
The serotonin 3 (5-HT3) receptor is a ligand gated ion channel unlike the other 5-HT receptors which are G protein coupled receptors. The functional 5-HT3 receptor forms a pentamer …
40
… HTR3A SNP (T allele of rs1062613 and G allele of rs2276302) were significantly associated with better clinical response to clozapine, after 100 million permutations (p=0.02). CYP1A2 …
41
Clozapine has been serving as the gold standard medication for patients with treatment-resistant schizophrenia who failed to respond to other antipsychotics. However, …
42
… the HTR3A receptor (rs2276302, rs1062613, rs1150226… rs2276302 and rs1062613 have shown nominally significant genotypic association. The two haplotypes composed of rs2276302…
43
Alcohol use disorders (AUD) with co-morbid antisocial personality disorder (ASPD) have been associated with serotonin (5-HT) dysfunction. 5-HT3 receptors are potentiated by ethanol …
44
Heroin addiction is a chronic complex disease with a substantial genetic contribution. This study was designed to identify gene variants associated with heroin addiction in African …
45
Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of …
46
Genetic variations in the serotonin receptor 3A (HTR3A) and 3B (HTR3B) genes, positioned in tandem on chromosome 11q23.2, have been shown to be associated …
47
We have been publishing a series of detailed maps of single-nucleotide polymorphisms (SNPs) detected within the genomic loci of 145 genes encoding drug-metabolizing enzymes …
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