CHROMOSOME 8 PSCA 8q24.3 GENE VIEW PSCA · 8q24.3 8q23 8q25 rs2294008 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs2294008 C / T · PSCA · 8q24.3 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ C 5′ 3′ C HETEROZYGOUS 5′ 3′ C 5′ 3′ T HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ T 5′ 3′ T C Cytosine — reference allele T Thymine — variant allele genetics.jdge.cc

rs2294008

Gene: PSCA — Prostate Stem Cell Antigen Chr 8:142680513 8q24.3 Intron Variant
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total C 0.548258T 0.451742CC 0.302185CT/TC 0.492145TT 0.205669pop=753,802
African C 0.58216T 0.41784CC 0.33913CT/TC 0.486056TT 0.174814pop=64,400
African American C 0.58108T 0.41892CC 0.337948CT/TC 0.486269TT 0.175783pop=62,122
African Others C 0.6115T 0.3885CC 0.371378CT/TC 0.480246TT 0.148376pop=2,278
Asian C 0.53497T 0.46503CC 0.305944CT/TC 0.458042TT 0.236014pop=13,728
East Asian C 0.52786T 0.47214CC 0.299889CT/TC 0.455942TT 0.244169pop=10,804
European C 0.5489T 0.4511CC 0.301924CT/TC 0.493953TT 0.204123pop=604,928
Latin American 1 C 0.53773T 0.46227CC 0.29162CT/TC 0.492214TT 0.216166pop=10,788
Latin American 2 C 0.45343T 0.54657CC 0.208734CT/TC 0.489401TT 0.301865pop=20,380
Other C 0.53999T 0.46001CC 0.295736CT/TC 0.488501TT 0.215762pop=30,960
Other Asian C 0.5612T 0.4388CC 0.328317CT/TC 0.4658TT 0.205882pop=2,924
South Asian C 0.5382T 0.4618CC 0.295892CT/TC 0.484567TT 0.21954pop=8,618

Studies20

Unread Studies20
1
PID
The association between PSCA gene polymorphism and hepatocellular carcinoma risk.
2
PID
Association of rs2294008 (PSCA) Gene polymorphism in Urothelial Bladder Cancer of South Indian Population.
3
PID
Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk.
4
PID
The landscape of 8q24 cytoband in gastric cancer (Review).
5
PID
Bladder cancer course, four genetic high-risk variants, and histopathological findings.
6
PID
Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.
7
PID
Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network.
8
PID
The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
9
PID
SNP rs2920280 in PSCA Is Associated with Susceptibility to Gastric Mucosal Atrophy and Is a Promising Biomarker in Japanese Individuals with Helicobacter pylori Infection.
10
PID
Hybridization chain reaction-mediated Fe(2)MoO(4) bimetallic nanozyme for colorimetric risk prediction of bladder cancer.
11
PID
The role of single-nucleotide polymorphisms of the 8q24 chromosome region in patients with concomitant bladder and prostate cancer.
12
PID
An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis.
13
PID
Single nucleotide polymorphisms of whole genes and atrophic gastritis susceptibility:a systematic review and meta-analysis.
14
PID
A single nucleotide polymorphism in Prostate Stem Cell Antigen is associated with endoscopic grading in Kyoto classification of gastritis.
15
PID
Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
16
PID
Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.
17
PID
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
18
PID
Predictive model for risk of gastric cancer using genetic variants from genome-wide association studies and high-evidence meta-analysis.
19
PID
Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
20
PID
Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
Curated Studies0

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0

No unused studies.