Genetics Research
rs2494750
Population Frequencies12
African
G 0.2055C 0.7945GG 0.037064GC/CG 0.336812CC 0.626125pop=5,558
African American
G 0.2028C 0.7972GG 0.036262GC/CG 0.333084CC 0.630654pop=5,350
African Others
G 0.274C 0.726GG 0.057692GC/CG 0.432692CC 0.509615pop=208
Asian
G 0.605C 0.395GG 0.385965GC/CG 0.438596CC 0.175439pop=114
East Asian
G 0.64C 0.36GG 0.431818GC/CG 0.409091CC 0.159091pop=88
European
G 0.06474C 0.93526GG 0.003973GC/CG 0.121538CC 0.874489pop=17,114
Latin American 1
G 0.184C 0.816GG 0.052632GC/CG 0.263158CC 0.684211pop=228
Latin American 2
G 0.261C 0.739GG 0.084788GC/CG 0.351621CC 0.563591pop=802
Other
G 0.177C 0.823GG 0.042129GC/CG 0.27051CC 0.687361pop=902
Other Asian
G 0.5C 0.5GG 0.230769GC/CG 0.538462CC 0.230769pop=26
South Asian
G 0.304C 0.696GG 0.098039GC/CG 0.411765CC 0.490196pop=102
Studies35
Unread Studies35 ▼
1
Latin America and the Caribbean (LAC) have higher prostate cancer (PCa) mortality rates than other regions, possibly due to disparities in detection and treatment, as well …
2
… rs2494750 CC genotype had significantly longer PFS compared to those with the rs2494750 … No significant difference in AKT1 rs2494750 genotype distribution was observed between …
3
This study assessed financial incentives aimed at improving OB/GYN availability in underserved Korean regions. A 10-year cross-sectional analysis found that while full-time OB/GYN …
4
PTEN (phosphatase and tensin homologue) is a tumour suppressor gene which is well known for its negative regulation on phosphatidylinositol 3-kinase (PI3K) pathway, …
5
Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period. …
6
Prostate cancer (PCa) is one of the most frequent neoplasms in men around the world. In recent years, the search for new biomarkers with greater prognostic potential …
7
… Сравнительный анализ распределен ия генотипов полиморфных локусов rs2494750 гена АКТ1 и rs17878362 гена TP53 в выборках больных с раком простаты и индивидов …
8
… Сравнительный анализ распределен ия генотипов полиморфных локусов rs2494750 гена АКТ1 и rs17878362 гена TP53 в выборках больных с раком простаты и индивидов …
9
三阴性乳腺癌(tnbc) 是一类治疗困难, 预后较差, 术后早期易复发且易转移的乳腺癌. 发病呈 低龄化趋势, 种族差异大, 具有明显的遗传易感性, 因此迫切需要阐明tnbc 的遗传风险因素, 找到…
10
This study was conducted to investigate the relationship between genetic variants in LKB1/AMPK/mTOR pathway and treatment outcomes of patients with non‐small cell lung cancer (…
11
Цель настоящего исследования–поиск ассоциаций генотипов и аллелей полиморфных локусов генов PTEN/PI3K/AKT пути: rs2494750 гена AKT1, rs2735343, rs2299941, …
12
… Another polymorphic variant rs2494750 of the gene AKT1 is associated with an increase in … of genotypes and alleles of polymorphic loci rs2494750 of the gene AKT1, rs2735343, …
13
Inflammation and one of its mediators, NF‐kappa B (NFκB), have been implicated in prostate cancer carcinogenesis. We assessed whether germline polymorphisms …
14
Breast cancer (BC) is the second most commonly diagnosed cancer in the world. BC develops due to dysregulation of transcriptional profiles, substantial interpatient variations, genetic …
15
… A multivariate statistical analysis adjusted for the determined risk factors indicated a protecting effect for genotypes CG and CG + GG for the rs2494750 AKT1gene (Table 2). A …
16
Molecular genetic mechanisms underlying initiation and progression of prostate cancer (PC), are not well defined due to high tumor heterogeneity, and lack of suitable biomarkers. …
17
This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non‐small cell lung cancer (…
18
… In analyses limited to men diagnosed with local or regional stage disease, a variant in AKT1, rs2494750, was also confirmed to be associated with PCSM risk (HR 0.81; p-value = 3.6 × …
19
This study was conducted to investigate the associations between polymorphisms of genes involved in LKB1 pathway and the prognosis of patients with non-small cell lung …
20
The immune system is a double-edged sword with regard to the prostate cancer (PCa) battle. Immunogenetics, the study of the potential role of immune-related polymorphisms, is taking …
21
… The association between polymorphisms of AKT1 rs2494750, … For AKT1 rs2494750 polymorphism, we have not found the … the correlation between rs2494750 polymorphism and the …
22
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of …
23
In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs…
24
… AKT1 rs2494750 G>C located in our target sequence, which we also observed in this study (data not shown). In addition, we analyzed the TFBS change and the corresponding …
25
AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) …
26
… Moreover, our meta-analysis observed no association of AKT1 rs2494750 and AKT2 … It was noted that significant publication bias was detected in the mini meta-analysis for rs2494750. …
27
… The rs635261 SNP is ∼3,700 bp downstream of RNASEL, the XRCC1 variant, rs915927, is a synonymous change at Pro206, and rs2494750 is ∼830 bp upstream of the AKT1 gene. …
28
Associations between single nucleotide polymorphisms (SNPs) at 5p15 (TERT-CLPTM1L) and multiple cancer types have been reported. We examined whether polymorphisms in the …
29
… 3 (1.5) rs2494750 …
30
… MDR analysis reveal interaction between rs2494750 and rs3803300 of v-AKT murine thymona viral oncogene homolog 1 (AKT1) and rs16917204, rs56164415 of Brain Derived …
31
Supplementary appendix 1: Full list of SNPs & genes that were examined. Supplementary appendix 2: Adjusted odds ratio (and 95% CI) for CLL by SNPs and ab_EBV positivity, …
32
Prostate cancer is the second leading cause of cancer-related deaths in men, accounting for more than 30,000 deaths annually. The purpose of this study was to test …
33
We report here the identification of a highly conserved haplotype, denoted H1 (ancestral) and H2 (derived), of three SNPs in high linkage disequilibrium present upstream of the AKT1 …
34
Estrogen promotes changes in cytoskeletal architecture not easily attributed to the biological action of estrogen receptors, ERα and ERβ. The Gs protein-coupled transmembrane …
35
There is a genetic variation happened “Single nucle constitutional variations found in germ cells and other tis (adenine, thymine, uracil, cytosine, and guanine) in the g set up 1% of the …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.