Genetics Research
rs3127573
Population Frequencies12
African
A 0.84855G 0.15145AA 0.721035AG/GA 0.255026GG 0.023939pop=59,986
African American
A 0.84866G 0.15134AA 0.72139AG/GA 0.254541GG 0.024069pop=57,916
African Others
A 0.8454G 0.1546AA 0.711111AG/GA 0.268599GG 0.02029pop=2,070
Asian
A 0.90948G 0.09052AA 0.825834AG/GA 0.167288GG 0.006878pop=17,156
East Asian
A 0.90772G 0.09228AA 0.822531AG/GA 0.17037GG 0.007099pop=12,960
European
A 0.883212G 0.116788AA 0.780721AG/GA 0.204982GG 0.014297pop=545,862
Latin American 1
A 0.9081G 0.0919AA 0.827925AG/GA 0.160352GG 0.011723pop=9,554
Latin American 2
A 0.94246G 0.05754AA 0.888922AG/GA 0.107075GG 0.004003pop=19,986
Other
A 0.8978G 0.1022AA 0.806503AG/GA 0.182585GG 0.010911pop=27,494
Other Asian
A 0.9149G 0.0851AA 0.836034AG/GA 0.157769GG 0.006196pop=4,196
South Asian
A 0.9268G 0.0732AA 0.856627AG/GA 0.140278GG 0.003094pop=3,878
Studies25
Unread Studies25 ▼
1
Chronic kidney disease is a growing burden, yet the genetic architecture of kidney function requires further investigation. We performed a genome-wide association study of estimated …
2
To investigate the allelic and genotypic frequencies of the two genetic variations, NC_000006.12: g.160275887C > T (rs662301) and NC_000006.12:g.160231826 T > C (…
3
Type 2 diabetes (T2D) is a common chronic disease affecting more than 420 million people worldwide. Metformin, a biguanide drug that lowers blood …
4
Chronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its predominant pathophysiologic driver…
5
Chronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its predominant pathophysiologic driver…
6
Creatinine, a clinical marker for kidney function, is predominantly cleared by glomerular filtration, with active tubular secretion contributing to about 30% of its renal clearance. Recent …
7
… Our finding of a C allele frequency for rs3127573 of 80.6%, and … [32], the SNP rs3127573 was associated with end-stage … , only the gene variant rs3127573 out of 212 candidate SNPs …
8
Organic cation transporter 2 (OCT2) is a renal carrier transporter protein found in the basolateral membrane of proximal epithelial cells, which facilitates active secretion of …
9
The World Health Organization (WHO) recommends dolutegravir in combination with a nucleos (t) ide reverse transcriptase inhibitor (NRTI) backbone as the preferred first-…
10
… In addition, two intron variants associated with serum creatinine elevation were identified: rs8068318 (17q23) and rs3127573 (6q25), VF = 27 % and 13 %, respectively. …
11
Клинический ответ на метформин сильно варьируется у пациентов с диабетом 2-го типа (СД2Т), что подчеркивает необходимость идентификации генетических компонентов, …
12
Type 2 diabetes mellitus (T2DM) is the most common form of diabetes, and is rising in incidence with widespread prevalence. Multiple gene variants are associated with glucose …
13
Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, …
14
Type 2 diabetes mellitus (T2DM) constitutes a major portion of Jordan’s disease burden, and incidence rates are rising at a rapid rate. Due to variability in the drug’s response between …
15
… For example, PLG is a partner to rs3127573 in the kidney, while in non-renal GTEx tissues, this variant is associated with the expression of SLC22A3. Another CKD-dt GWAS eSNP (…
16
… In the case of the latter, genome-wide association studies have identified a single nucleotide polymorphism (rs3127573 and rs2504954) in the OCT2 gene that is associated with serum …
17
Plasma TFV concentrations were measured using a validated reversedphase high-performance liquid chromatography assay. 6 This assay was internally validated, and the average …
18
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P= 10− 10 to 10− 15)…
19
Chronic kidney disease (CKD) has become a serious public health problem because of its associated morbidity, premature mortality, and attendant healthcare costs. The rising number …
20
Plasminogen is the precursor of the serine protease plasmin, a central enzyme of the fibrinolytic system. Plasma levels of plasminogen vary by almost 2-fold among healthy individuals, …
21
… polymorphisms: 87 rs3127573 and rs316019. The first SNP, rs3127573 in the SLC22A2 5′ … Therefore, in the subsequent manuscript 96 sections we refer to rs3127573 and rs316009. …
22
… SLC22A2 polymorphisms: rs3127573 and rs316019. The first SNP, rs3127573 in the SLC22A2 5… Therefore, in the subsequent manuscript sections we refer to rs3127573 and rs316009. …
23
… SLC22A2 polymorphisms: rs3127573 and rs316019. The first SNP, rs3127573 in the SLC22A2 5… Therefore, in the subsequent manuscript sections we refer to rs3127573 and rs316009. …
24
… SLC22A2 single nucleotide polymorphisms (SNPs), rs3127573 and rs316009, were genotyped in 1,142 ESRD patients receiving renal transplantation and 1,186 kidney donors as …
25
Клинический ответ на метформин сильно варьируется у пациентов с диабетом 2-го типа (СД2Т), что подчеркивает необходимость идентификации генетических компонентов, …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
No unused studies.