Genetics Research
rs3743527
Gene: ABCC1 — ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)
Chr 16:16141824
16p13.11
3 Prime UTR Variant
Population Frequencies12
African
C 0.84711T 0.15289CC 0.721867CT/TC 0.250477TT 0.027656pop=53,442
African American
C 0.8464T 0.1536CC 0.72062CT/TC 0.25155TT 0.027829pop=51,600
African Others
C 0.867T 0.133CC 0.756786CT/TC 0.220413TT 0.022801pop=1,842
Asian
C 0.62439T 0.37561CC 0.394351CT/TC 0.460076TT 0.145573pop=11,046
East Asian
C 0.6192T 0.3808CC 0.38805CT/TC 0.462232TT 0.149718pop=8,870
European
C 0.789087T 0.210913CC 0.62333CT/TC 0.331514TT 0.045156pop=489,680
Latin American 1
C 0.8277T 0.1723CC 0.687434CT/TC 0.280459TT 0.032107pop=9,406
Latin American 2
C 0.71149T 0.28851CC 0.50942CT/TC 0.404132TT 0.086448pop=13,164
Other
C 0.75779T 0.24221CC 0.578787CT/TC 0.357996TT 0.063217pop=17,084
Other Asian
C 0.6457T 0.3543CC 0.420037CT/TC 0.451287TT 0.128676pop=2,176
South Asian
C 0.5338T 0.4662CC 0.286923CT/TC 0.493819TT 0.219258pop=3,074
Studies68
Unread Studies68 ▼
1
Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia
2
… Previous associations of ABCC2 rs8287710 that have been reported in haematological malignancies [47], and ABCC1 rs3743527, linked to decreased LVEF in childhood acute …
3
… Carrying TT genotypes for the ABCC1-rs3743527 variant was associated with a reduced … lower in patients with a combination of ABCC1-rs3743527-TT and ABCC1-rs246221-TC or TT …
4
Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study Frontiers in …
5
Clinical and cost-effectiveness of pharmacogenomic testing for anthracycline-induced cardiotoxicity in childhood cancer: a systematic review and meta-analysis Frontiers in …
6
Acute lymphoblastic leukemia (ALL) incidence has been linked to different genetic variations. Neutrophil cytosolic factor 4 (NCF4)(rs1883112) single nucleotide …
7
The purpose of this study was to comprehensively analyze the prediction role of NADPH oxidase (NOX)-related polymorphisms (NCF4: rs1883112, CYBA: rs4673, RAC2: rs13058338) …
8
Vincristine is a cornerstone chemotherapeutic agent widely used for the treatment of various pediatric cancers. However, its clinical utility is often compromised by the occurrence of …
9
Drug-induced cardiovascular toxicity remains a significant cause of heart-related morbidity and mortality. This could be clinical manifestations as arrhythmia, prolongation of QT interval, …
10
… with acute lymphoblastic leukaemia, where the rs3743527 was found to provide a statistically … findings regarding the rs3743527 polymorphism. Similar to rs3743527, the influence of the …
11
Anthracyclines are a crucial component of chemotherapy regimens used to treat a range of malignancies in children and adults. However, cardiac dysfunction and heart failure …
12
… Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic …
13
Advances in the understanding of the pathobiology of childhood B-cell acute lymphoblastic leukemia (B-ALL) have led towards risk-oriented treatment regimens and …
14
… In contrast to CBR3 rs1056892, the heterozygous allele ABCC1 rs3743527 correlated with resistance to anthracycline cardiotoxicity in ALL patients. In another study, heterozygosity of …
15
Цель. Выявить однонуклеотидные полиморфизмы, достоверно ассоциированные с кардиоваскулярной токсичностью у пациентов онкогематологического профиля, …
16
… Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic …
17
… rs1045642, ABCC1 rs4148350, and ABCC1 rs3743527 and cardiotoxicity in breast cancer. All … However, our results indicated that ABCB1 rs1045642 and ABCC1 rs3743527 did not …
18
… TT homozygosity of the SNV rs3743527 of gene ABCC1 is … A SNV in this gene such as rs3743527 could be implicated … , TT homozygosity of SNV rs3743527 of the ABBC1 gene shows …
19
… варианты rs246221 и rs3743527 влияют на антрациклин-индуцированную дисфункцию ЛЖ. Так, генотип TT rs3743527 гена ABCC1 и комбинация генотипов TT rs3743527 и TC …
20
… Также, по некоторым сведениям, генотипы полиморфизмов rs3743527 и rs246221 гена ABCC1 могут влиять на развитие АИК, хотя вклад каждого отдельного полиморфизма …
21
В работе представлен обзор данных о генетических полиморфизмах, ассоциированных с эффективностью и безопасностью противоопухолевых антибиотиков. Рассмотрены …
22
The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of …
23
… PI: 1,6–8,4; p = 0,001), o rs3743527 ir rs246221 buvo susiję su vaikų širdies disfunkcija gydant ūminę limfoblastinę leukemiją [165]. Priešingai, kiti toje pačioje studijoje analizuoti …
24
… Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic …
25
Most commonly diagnosed cancer pathologies in the pediatric population comprise leukemias and cancers of the nervous system. The percentage of cancer survivors increased from …
26
… In a study of 235 pediatric acute lymphoblastic leukemia patients, ABCC1 rs3743527 TT or TC genotype [121] and ABCC5 rs7627754 TT genotype were associated with an 8% …
27
… In a pediatric cohort with acute lymphoblastic leukemia, patients with SNP rs3743527 TT in ABCC1 had decreased LV fractional shortening at follow-up (8). The combination of either …
28
In Europe, an average of 12-15 new patients is diagnosed with malignancies per 100,000 children a year. Among childhood cancers, the most common is acute lymphoblastic leukemia …
29
In childhood cancer survivors (survival of 5 years or more after diagnosis), cardiac toxicity is the most common nonmalignant cause of death attributed to treatment-related …
30
… Furthermore, a number of genetic polymorphisms in the ABCC1 gene (eg, rs3743527 and rs246221) is associated with the development of anthracycline-induced cardiotoxicity.However…
31
… Due to the importance of identifying risk factors for developing ALL, the objective of the present study is to determine if the ABCC1 rs3743527, NCF4 rs1883112 and CBR3 rs1056892 …
32
… , CBR3 rs1056892 and ABCC1 rs3743527 genotype status and echocardiographic parameters … Heterozygosis for the ABCC1 rs3743527 allele was associated with protection from …
33
… Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic …
34
Methotrexate (MTX), an antimetabolite for the treatment of leukemia, could cause neutropenia and subsequently fever, which might lead to treatment delay and affect prognosis. Here, …
35
… Another study performed on the pediatric population diagnosed with ALL revealed that the nucleotide polymorphism rs3743527 that occurs within the 3’ UTR of ABCC1 decreased the …
36
… Other ABCC1 variants associated with ACT include a variant in the 3′ UTR (C>T, rs3743527) associated with decreased SF in childhood ALL survivors, a G>T missense variant …
37
… Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic …
38
… ABCC1 rs3743527 and rs246221 were associated with lower left ventricular ejection fraction shortening after anthracycline treatment, contributing to cardiotoxicity development (29). …
39
… variants associated with a higher risk of ACT across various pediatric malignancies [23,24] , and the ABCC5 rs7627754 TT genotype [21] as well as ABCC1 gene variants (rs3743527 …
40
It was previously and alarmingly reported that adverse drug reactions (ADRs) represent the fourth leading cause of death in the USA [1]. A recent review (2015) showed that 3.6% of …
41
Adverse drug reactions (ADRs) constitute the fourth leading cause of death and their incidence is steadily increasing. Cardiovascular toxicity is one of the most common and serious …
42
… To examine the presence of associations between NCF4 rs1883112, CBR3 rs1056892 and ABCC1 rs3743527 genotype status and echocardiographic parameters indicative …
43
Cardiovascular diseases are the main cause of treatment-related morbidity and mortality in childhood cancer patients. Anthracyclines, one of the most common …
44
Although cardiotoxicity has been widely concerned, the study of early-onset cardiotoxicity is insufficient and it is difficult to explain the occurrence of cardiotoxicity only by …
45
Recent therapeutic advances have significantly improved the short‐ and long‐term survival rates in patients with heart disease and cancer. Survival in cancer patients may, however, be …
46
Anthracycline‐induced cardiotoxicity ( ACT ) is a severe adverse drug reaction for a subset of children treated with anthracyclines as part of chemotherapy protocols. The identification of …
47
Many paediatric patients with cancer experience significant chemotherapy side effects. Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs). We …
48
Neutropenia is a common dose-limiting toxicity associated with irinotecan treatment. Although UGT1A1 variants have been associated with neutropenia, a fraction of neutropenia risk …
49
Chemotherapy-related cardiac dysfunction is a significant side effect of anticancer treatment. Risk stratification is based on clinical- and treatment-related risk factors that do not …
50
The aim of our study was to set up a panel for targeted sequencing of chemoresistance genes and the main transcription factors driving their expression and to evaluate their predictive …
51
Interindividual and interethnic differences in response to antiretroviral drugs (ARVs) are influenced by genetic variation. The few genomic studies conducted among African-Americans …
52
The solute carrier superfamily comprises of uptake transporters that can contribute to the absorption and elimination of a broad array of clinically important drugs. Recent studies have …
53
… poly-miRTS of anthracycline-pathway genes and CR or OS/RFS of AML; however, we did show that four poly-miRTS were associated with chemotherapy toxicity, ie, ABCC1 rs3743527, …
54
Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. Objective and Method: We evaluated the distribution of single …
55
… Of note, one of the most significant SNPs in ABCC1 (rs3743527) was also associated with anthracycline-induced cardiotoxicity in childhood ALL, suggesting its possible involvement in …
56
Advances in our understanding of the pathobiology of childhood acute lymphoblastic leukemia (ALL) have led to risk-targeted treatment regimens and remarkable …
57
The present study aims at evaluating the association between seven single nucleotide polymorphisms (SNPs) in five genes involved on antiretroviral pharmacokinetic pathways and …
58
… Our results indicate that certain genotypes of the ABCC1 rs3743527 or rs246221 SNPs might influence the development of cardiotoxicity after anthracycline treatment in the patient …
59
… A kemoterápia után az rs3743527 TT genotípusú betegek a kezelés befejezésekor meghatározott szívfunkciója szignifikánsan alacsonyabb volt (34,0%), mint a CC (39,5%) és CT (39,3 …
60
… Linkage between SNPs from different genes were determined between ABCC1 (rs3743527) and ABCC6 (rs212097) genes (|D| = 1, LOD = 13.44; Figure 2 ), between CAR (rs3003596) …
61
… Results: No significant correlation was seen in rs3743527 … In our sample the average frequencies of rs3743527 C and T … frequencies of rs129081 and rs3743527 variants in the patient …
62
… Two SNPs, the ABCC1 rs3743527 and ABCC1 rs246221 were found to be associated with … was decreased in the patients with the ABCC1 rs3743527 TT genotype at the end of the …
63
Tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NKK) is a well defined carcinogen that can induce lung cancer. Genetic …
64
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) is a well defined carcinogen that can induce lung cancer. Genetic polymorphisms …
65
Drug resistance is a severe limitation of chemotherapy of various malignancies. In particular efflux transporters of the ATP-binding cassette family such as ABCB1 (P-glycoprotein), the …
66
… In this present study, two SNPs, rs3743527 and rs246221 were found to influence the cardiac … The rs3743527 SNP is located in the 3’untranslated region (UTR) of the ABCC1 gene. In …
67
Since the pharmacogenetics and pharmacogenomics (PGx) field started to rise, the information about the relationship between actionable genes, genotypes, and response to drugs has …
68
Aнтpaциклины являютcя вaжным кoмпoнeнтoм мнoгиx cxeм xимиoтepaпии, oднaкo иx пpимeнeниe cвязaнo c пoвышeнным pиcкoм paзвития дисфункции миокарда [1, 6, 20, 23, …
Curated Studies0 ▼
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