Genetics Research
rs3773678
Population Frequencies12
African
A 0.61519G 0.38481AA 0.379413AG/GA 0.471546GG 0.149041pop=52,576
African American
A 0.6112G 0.3888AA 0.374235AG/GA 0.473931GG 0.151833pop=50,674
African Others
A 0.7213G 0.2787AA 0.51735AG/GA 0.407992GG 0.074658pop=1,902
Asian
A 0.18424G 0.81576AA 0.033118AG/GA 0.302249GG 0.664633pop=11,474
East Asian
A 0.1717G 0.8283AA 0.027517AG/GA 0.288273GG 0.684211pop=9,158
European
A 0.125593G 0.874407AA 0.015893AG/GA 0.2194GG 0.764707pop=547,786
Latin American 1
A 0.277G 0.723AA 0.075811AG/GA 0.402379GG 0.52181pop=8,574
Latin American 2
A 0.14895G 0.85105AA 0.021868AG/GA 0.254156GG 0.723976pop=17,926
Other
A 0.20337G 0.79663AA 0.054616AG/GA 0.29751GG 0.647874pop=17,028
Other Asian
A 0.234G 0.766AA 0.055268AG/GA 0.357513GG 0.587219pop=2,316
South Asian
A 0.2446G 0.7554AA 0.062453AG/GA 0.36427GG 0.573277pop=8,038
Studies56
Unread Studies56 ▼
1
… showed that the homozygous recessive genotype GG rs3773678 DRD3 was significantly associated with the development of Parkinson's disease in the Caucasian population of …
2
Partial pathogenesis is shared in substance- and nonsubstance-related addictions (eg, pathological gambling, Internet addiction, binge-eating disorder) due to similar symptomatology …
3
Cloninger’s temperament dimensions have been studied widely in relation to genetics. In this study, we examined Cloninger’s temperament dimensions grouped with cluster …
4
Антимонопольное регулирование считается главным направлением в предпринимательской деятельности, так как оно нацелено на формирование конкуренции, а также …
5
БИОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ Page 1 Федоренко ОЮ, Иванова СА, Корнетова ЕГРоль полиморфизма генов дофаминовой и глутаматной систем… Сибирский вестник …
6
… However, a significant difference at the 0.05 level in the allele frequencies of rs3773678 between the Sousse and Libya populations was demonstrated (p = 0.014). In addition, the allele …
7
Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous group of neurodevelopmental disorders. Despite the extensive efforts of scientists, the …
8
Parkinson’s disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor …
9
There is sufficient evidence that interference of dopaminergic neurotransmission contributes to the therapeutic effects of antidepressants in unipolar and bipolar depression…
10
Dopamine (DA) integrity is suggested as a potential cause of individual differences in working memory (WM) performance among older adults. Still, the principal dopaminergic …
11
Introduction: Extrapyramidal disorders form the so-called extrapyramidal syndrome (EPS), which is characterized by the occurrence of motor disorders as a result of damage to the …
12
Использование антипсихотических средств ассоциировано с повышенным уровнем пролактина. Лекарственно-индуцированная гиперпролактинемия (ГП) имеет не только …
13
Levodopa remains the gold standard of treating Parkinson's disease (PD). However, the inevitable complication of levodopa therapy is druginduced dyskinesias, which significantly …
14
Препараты леводопы остаются «золотым» стандартом лечения болезни Паркинсона (БП). Однако неизбежным осложнением терапии леводопой является развитие …
15
… We got statistically significant results for alleles of polymorphic variant rs3773678 of DRD3 receptor gene (c2 = 4.940, p = 0.030). We found that allele C are significantly associated with …
16
… To measure variant rs3773678 of DRD3 receptor gene (c2 = 4.940, the cognitive performance, we used a battery consisting of p = 0.030). We found that allele C are significantly asso- …
17
The main method to treatment of schizophrenia is long-term antipsychotic therapy, which not only improves the long-term prognosis of the disease and facilitates its …
18
The effect of risperidone treatment in patients with schizophrenia varies according to the dopamine receptor genes. This study aimed to evaluate the relationship between …
19
Было проведено генотипирование 28 полиморфизмов 5 генов дофаминовых рецепторов и 12 полиморфизмов гена дофаминового транспортера у 475 больных …
20
Леводопа-индуцированная дискинезия является серьёзным и отягчающим лечение болезни Паркинсона побочным эффектом. Данное исследование было проведено для …
21
Лекарственно-индуцированная гиперпролактинемия при приеме антипсихотических средств изучена недостаточно. Целью работы является изучение полиморфных …
22
Tardive dystonia due to D2 antagonists or other agents is a potentially severe extrapyramidal side effect emerging after long-term drug treatment, prevalent but not limited to psychiatric …
23
Long-term levodopa treatment of Parkinson's disease (PD) is frequently complicated by spontaneously occur ring involuntary muscle movements called levodopa-induced …
24
Essential hypertension (EH) is one of the major cardiovascular diseases. Recent studies demonstrated that dopamine D1 and D3 receptor gene polymorphisms (DRD1 and …
25
… Studies have shown that DRD3 rs3773678 and rs7638876 were associated with nicotine addiction [36, 71], and PG studies have similar findings [29]. …
26
У больных шизофренией, длительно получающих антипсихотическую терапию, кроме основного нейролептического эффекта часто наблюдаются побочные действия …
27
Основным способом лечения шизофрении является длительная антипсихотическая терапия, которая улучшает долгосрочный прогноз заболевания и способствует его …
28
… Выявлены достоверные ассоциации по полиморфизмам rs11721264, rs3773678, rs167771, rs324035, что подтверждает вовлеченность полиморфных особенностей генов …
29
Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression
Alterations in the monoaminergic neurotransmission systems are suspected to be involved in the etiology of neuropsychiatric disorders, including depression. The role of these …
30
To investigate the association between dopamine receptor DRD3 gene tag single nucleotide polymorphisms (SNPs) and the risk of Parkinson's disease (PD). …
31
Delay discounting is a potential etiological factor in adolescents' alcohol use, making it important to understand its antecedents. Family disorganization might contribute to …
32
Long-term levodopa treatment of Parkinson's disease (PD) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. The …
33
Our previous studies showed expression of Runx1t1 increased during hippocampal neurogenesis. It was hypothesised that Runx1t1 involved the neural development in …
34
PD is one of the most serious and widespread neurodegenerative diseases characterized by chronic progressive course, dysfunction of the basal ganglia and severe …
35
Levodopa-induced dyskinesias (LID) are involuntary muscle movements that occur as a consequence of chronic levodopa (L-DOPA) treatment. LID are a substantial barrier to effective …
36
Early or R1 motor response from the orbicularis oculi (o. oculi) muscle is obtained only unilaterally from ipsilateral supraorbital nerve stimulation, while the late or R2 …
37
Many patients with myotonic dystrophy type 1 (DM1) develop muscular atrophy and weakness accompanied with myotonia in their adulthood. Some patients with DM1 …
38
Delay discounting is a behavioral economic index of impulsivity that reflects preferences for small immediate rewards relative to larger delayed rewards. It has been …
39
Associations of polymorphisms from dopaminergic neurotransmitter pathway genes have mostly been reported in Caucasian ancestry schizophrenia (SZ) samples. As …
40
Studies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide …
41
Schizophrenia is a complex disease, with both genetic and environmental influence. Machine learning techniques can be used to associate different genetic variations at different genes …
42
Numerous genetic linkages, association studies have been performed in different ethnic groups and revealed many susceptibility loci and genes for nicotine dependence. However, …
43
Discovery in Databases process (KDD), is the process of extracting patterns from large data sets by combining methods from statistics and artificial intelligence with database …
44
Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal …
45
Single nucleotide polymorphisms (SNPs) can be used as inputs in disease computational studies such as pattern searching and classification models. Schizophrenia is an example of a …
46
Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior …
47
We present a schizophrenia association study using an extensive linkage disequilibrium (LD) mapping approach in seven candidate genes with a well established link to dopamine, …
48
Genetic studies estimate that 65–78% of the vulnerability risk for cocaine dependence is heritable (Kendler and Prescott, 1998); however, identification of genetic susceptibility factors …
49
The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for …
50
The study objective was to evaluate variations in genes implicated in antidepressant mechanism of action for association with response to duloxetine treatment in …
51
Nicotine is the primary addictive component of tobacco that motivates continued use. Studies have demonstrated that individual vulnerability to nicotine dependence (ND) is influenced …
52
… The SNP rs3773678 located in the downstream intron was in much weaker LD with these markers (D′≈0.20), but this was not the case for another intron, SNP rs2134655. …
53
The dopamine hypothesis is one of the common and long-term theories of the pathogenesis of schizophrenia [1]. Initially, it was based on indirect evidence, and it was unclear what role …
54
Discovery in Databases process (KDD), is the process of extracting patterns from large data sets by combining methods from statistics and artificial intelligence with database …
55
Роль полиморфизма генов дофаминовой и глутаматной систем в клинической гетерогенности шизофрении и развитии антипсихотик-индуцированных побочных эффектов …
56
Depression is a worldwide leading cause of morbidity and disability. Genetic studies have recently begun to elucidate its molecular aetiology. The authors investigated …
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