rs386833787

Systemic sclerosis is a rare autoimmune disease of the connective tissue that affects mostly women. It is characterized by fibrosis and inflammation of the skin, blood vessels and internal organs. Being a mult ifactorial disease, it is believed to occur in genetically susceptible individuals after the effect of various environmental triggers. Vitamin D3 is a well-studied molecule with a plethora of functions, including regulation of the immune system. Due to this trait, vitamin D deficiency is believed to play a crucial role in the development of various diseases of the immune system. During this master thesis, a number of single nucleotide polymorphisms (SNPs) were investigated on vitamin D-related genes, regarding their relationship with systemic sclerosis susceptibility, as well as whole vitamin D serum levels.

2019 · Δ Πλαγεράς