CHROMOSOME 17 ABCC3 17q21.33 GENE VIEW ABCC3 · 17q21.33 17q20 17q22 rs4148412 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs4148412 T / A · ABCC3 · 17q21.33 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ T 5′ 3′ T HETEROZYGOUS 5′ 3′ T 5′ 3′ A HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ A 5′ 3′ A T Thymine — reference allele A Adenine — variant allele genetics.jdge.cc

rs4148412

Gene: ABCC3 — ATP Binding Cassette Subfamily C Member 3 Chr 17:50656454 17q21.33 Intron Variant
NCBI ↗ Research Rabbit ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total T 0.355919C 0.644081TT 0.127833TC/CT 0.456171CC 0.415996pop=488,654
African T 0.42288C 0.57712TT 0.178551TC/CT 0.488666CC 0.332782pop=42,352
African American T 0.42294C 0.57706TT 0.178804TC/CT 0.488268CC 0.332928pop=41,084
African Others T 0.4211C 0.5789TT 0.170347TC/CT 0.501577CC 0.328076pop=1,268
Asian T 0.2693C 0.7307TT 0.073325TC/CT 0.391953CC 0.534722pop=9,792
East Asian T 0.2745C 0.7255TT 0.07708TC/CT 0.39481CC 0.52811pop=7,862
European T 0.358393C 0.641607TT 0.128046TC/CT 0.460693CC 0.41126pop=393,624
Latin American 1 T 0.3475C 0.6525TT 0.131031TC/CT 0.432961CC 0.436008pop=7,876
Latin American 2 T 0.22734C 0.77266TT 0.053542TC/CT 0.347603CC 0.598855pop=16,772
Other T 0.33932C 0.66068TT 0.113463TC/CT 0.451704CC 0.434833pop=12,092
Other Asian T 0.2482C 0.7518TT 0.058031TC/CT 0.380311CC 0.561658pop=1,930
South Asian T 0.2683C 0.7317TT 0.078425TC/CT 0.379759CC 0.541816pop=6,146

Studies8

Unread Studies8
1
… Other variants identified in ABCC3 include rs4148412 (allele A) and rs35364174 (allele G). Although these variants are intronic and do not alter the protein structure, they exhibit a …
2
Фармакогенетика вивчає взаємозв’язок між індивідуальною генетичною характеристикою людини та реакцією організму людини на дію різних лікарських засобів, зокрема, …
3
Pharmacogenetics studies the relationship between a person's individual genetic characteristics and the human body's response to the action of various drugs, particularly the …
4
Morphine has been widely used in moderate and severe cancer pain, particularly in palliative care. However, up to 30% of patients do not respond to morphine and have poor outcomes …
5
Personalized pediatric anesthesia considering omics, is a novel science in neonates, infants, and children that can improve perioperative care and reduce the complications and …
6
We conducted a scoping review on genetic polymorphisms associated with opioid intake-related adverse patient outcomes including behavioral, physiological and clinical outcomes. …
7
… 接受扁桃体切除术的儿童,结果显示,rs4148412 AA 和rs4973665 CC 基因型儿童吗啡葡糖苷 类化合 物的清除率增加,rs4148412 位点的等位基因A 和 rs729923 位点的等位基因G 分别导致…
8
… , rs414812) and RD leading to prolonged PACU stay (prolonged RD) supported by increased formation clearance of morphine glucuronides in children with ABCC3 rs4148412 AA and …
Curated Studies0

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0

No unused studies.