Genetics Genetics Research
CHROMOSOME 10 INTERGENIC GENE VIEW INTERGENIC ?q23 ?q25 rs4409764 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs4409764 T / A · INTERGENIC HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ T 5′ 3′ T HETEROZYGOUS 5′ 3′ T 5′ 3′ A HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ A 5′ 3′ A T Thymine — reference allele A Adenine — variant allele genetics.jdge.cc

rs4409764

Gene: INTERGENIC — Intergenic / Genome-wide Chr 10:99524480
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

Sort by
Total T 0.492916G 0.507084TT 0.246422TG/GT 0.492988GG 0.26059pop=620,652 ↬
African T 0.56491G 0.43509TT 0.322122TG/GT 0.485585GG 0.192293pop=61,604
African American T 0.5645G 0.4355TT 0.321933TG/GT 0.485136GG 0.192931pop=59,472
African Others T 0.5765G 0.4235TT 0.327392TG/GT 0.498124GG 0.174484pop=2,132
Asian T 0.45002G 0.54998TT 0.208462TG/GT 0.48312GG 0.308418pop=13,566
East Asian T 0.44569G 0.55431TT 0.204141TG/GT 0.483102GG 0.312756pop=10,238
European T 0.489038G 0.510962TT 0.241138TG/GT 0.495799GG 0.263063pop=488,940
Latin American 1 T 0.519G 0.481TT 0.281657TG/GT 0.474696GG 0.243647pop=9,366
Latin American 2 T 0.39692G 0.60308TT 0.163349TG/GT 0.467141GG 0.36951pop=17,986
Other T 0.48786G 0.51214TT 0.242653TG/GT 0.490421GG 0.266926pop=26,202
Other Asian T 0.4633G 0.5367TT 0.221755TG/GT 0.483173GG 0.295072pop=3,328
South Asian T 0.3782G 0.6218TT 0.145248TG/GT 0.465863GG 0.388889pop=2,988

Studies3

Unread Studies3 ▼
1

Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population.

Study ↗ PDF ↗
PID
Inflammatory bowel diseases (IBD) are chronic gastrointestinal inflammatory conditions comprising two major subtypes: Crohn's disease (CD) and ulcerative colitis (UC). The incidence of IBD is increasing in Asian countries including Malaysia. The aim of this study was to determine whether 32 single nucleotide polymorphisms (SNPs) strongly associated with IBD from genome-wide association studies, performed mainly in Caucasian populations, are associated with IBD in a Malaysian population, correlat…

2022 · Luu LDW, Popple G, Tsang SPW et al.

2

Polymorphisms of the TNF Gene and Three Susceptibility Loci Are Associated with Crohn's Disease and Perianal Fistula Crohn's Disease: A Study among the Han Population from South China.

Study ↗ PDF ↗
PID
BACKGROUND Although 90 susceptibility loci of Crohn's disease (CD) have been confirmed in the Asian population, susceptibility genes for perianal fistula of CD (pCD) in this population remain unknown. This study explored susceptibility genes for CD and pCD in the Han population from South China. MATERIAL AND METHODS In total, 490 patients diagnosed with CD between July 2012 and June 2016 at the Sixth Affiliated Hospital of Sun Yat-sen University were included and divided into the CD group (n=240…

2019 · Zhang M, Wang X, Jiang X et al.

3

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

Study ↗ PDF ↗
PID
Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Using the ImmunoChip custom single-nucleotide polymorphism array design…

2015 · Yang SK, Hong M, Choi H et al.

Curated Studies0 ▼

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0 ▼

No unused studies.