Genetics Research
rs4436578
Population Frequencies12
African
C 0.52357T 0.47643CC 0.276203CT/TC 0.494736TT 0.229061pop=50,528
African American
C 0.52023T 0.47977CC 0.27244CT/TC 0.495584TT 0.231976pop=48,686
African Others
C 0.6118T 0.3882CC 0.375679CT/TC 0.472313TT 0.152009pop=1,842
Asian
C 0.4598T 0.5402CC 0.216905CT/TC 0.485809TT 0.297286pop=9,654
East Asian
C 0.4739T 0.5261CC 0.229796CT/TC 0.488252TT 0.281952pop=7,746
European
C 0.119377T 0.880623CC 0.014845CT/TC 0.209065TT 0.776091pop=405,530
Latin American 1
C 0.2516T 0.7484CC 0.064426CT/TC 0.374276TT 0.561298pop=8,630
Latin American 2
C 0.18714T 0.81286CC 0.038008CT/TC 0.298257TT 0.663735pop=12,734
Other
C 0.21159T 0.78841CC 0.058025CT/TC 0.307127TT 0.634848pop=12,236
Other Asian
C 0.4025T 0.5975CC 0.16457CT/TC 0.475891TT 0.359539pop=1,908
South Asian
C 0.2256T 0.7744CC 0.05114CT/TC 0.34886TT 0.6pop=6,140
Studies39
Unread Studies39 ▼
1
The role of neurotransmitter systems in the pathology and management of psychiatric disorders is well documented. Targeting these systems has remained the mainstay of standard …
2
Pharmacogenetic testing (PGx) of polymorphisms that alter the expression of genes asso-ciated with the distribution and response to antipsychotics (APs) can replace the" trial and error…
3
Antipsychotic-induced weight gain (AIWG) is a prevalent and clinically significant side effect that compromises treatment adherence and exacerbates metabolic health risks in …
4
Metabolic syndrome (MetS) is a cluster of interrelated conditions primarily driven by excessive caloric intake, physical inactivity, and excess abdominal fat. Core features include …
5
El fentanilo, un opioide sintético de alta potencia, se ha convertido en uno de los principales agentes implicados en la actual crisis de opioides en Estados Unidos, con importantes …
6
In 2023, 3651 Ohioans died because of an opioid overdose. Of those opioid overdoses, 3579 (98%) of which were attributed to fentanyl. We evaluated the association between 180 …
7
… It has been found that the DRD2 rs4436578*C genetic variant might have a protective role against schizophrenia in Armenians [32]. The A2B1D2 haplotype of DRD2 genes (Taq 1 A, B, …
8
… Genotyping of two single nucleotide polymorphisms rs1799732 and rs4436578 of the dopamine D2 receptor gene (DRD2) was performed in a population of 471 patients. The results …
9
… The present study is aimed at studying the role of allelic variants rs1799732, rs4436578 of the dopamine D2-receptor gene ( DRD2 ) in the pathogenesis of the metabolic syndrome in …
10
… Носительство генотипа DRD2 rs4436578-CС связано с высоким риском увеличения массы тела, вызванным длительным лечением ААП (клозапин, оланзапин или РСП), у …
11
Neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit/hyper-activity disorder (ADHD), represent a group of conditions that manifest early in …
12
… Our findings indicate young women with variant genotypes for two DRD2 SNPs (rs4436578 and rs4648318) and meeting a clinical screening threshold for elevated depressive …
13
… namely DRD2 rs4436578*C and HTR2A rs6314*A are underrepresented in the group of patients compared to healthy subjects. After the correction for multiple testing, the rs4436578*C …
14
A better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National …
15
… The role of DRD2 rs4436578-C in weight gain induced by atypical antipsychotics is verified in 479 chronic schizophrenic patients under long-term treatment of clozapine, olanzapine, or …
16
The D2 dopamine receptor (DRD2) has been extensively investigated and has been associated with the occurrence of neuropsychiatric disorders. Polymorphisms in the …
17
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (LEP) rs7799039, leptin receptor …
18
Second-generation antipsychotic substances, as compared with first-generation antipsychotics, are more effective in relation to psychotic symptoms and have significantly lower …
19
Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the …
20
Антипсихотические препараты второго поколения, по сравнению с антипсихотическими препаратами первого поколения, наиболее эффективны в отношении психотических …
21
The purpose of this study was to explore the association of genetic polymorphism of genes related to pharmacokinetics or pharmacodynamics with insulin resistance in children and …
22
We aimed to study the association of urine fluoride with intelligence quotient (IQ) in children with a careful consideration of up to 30 potential confounding factors as well as …
23
… Two SNPs in the DRD2 dopamine receptor gene, rs4436578 and rs4648318, were significantly associated (P < 0.05) with indoor tanning addiction after multiple testing adjustment …
24
Atypical antipsychotics are commonly prescribed for the treatment of psychiatric disorders such as schizophrenia. However, long term use of atypical antipsychotics lead to metabolic …
25
Heroin and drug dependence are major contributors to global health burden worldwide, but their underlying mechanisms remain elusive and may vary from population to population. …
26
Although several studies suggest that dopamine D2 receptor (DRD2) gene may contribute to creativity, the relationship between DRD2 and creativity still needs to be further validated. …
27
The purpose of this study was to evaluate the association of pharmacogenomic factors and clinical outcome in autistic children and adolescents who were treated with risperidone for …
28
Серьезными побочными эффектами антипсихотиков второй генерации (АВГ) являются метаболические нарушения в виде увеличения массы тела и формирования ожирения…
29
Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. …
30
The traditional approach to selecting antipsychotic medication involves little more than trial and error. Recent advances in genetics and molecular science offer the hope of a ‘…
31
Gene variations related to the dopaminergic pathway have been implicated in a number of neuropsychiatric disorders, including post-traumatic stress disorder (PTSD). …
32
The use of second-generation antipsychotic medications can result in the development of severe side effects such as weight gain and metabolic syndrome. Previous studies have …
33
… [24] обнаружили четкую связь между носительством DRD2 rs4436578-C/C и НМТ по сравнению с носителями аллеля Т [24]. Другой полиморфизм гена DRD2, rs2440390(A/G) …
34
One critical step toward to a better understanding of creativity is to unveil its underlying genetic architectures. Recently, several studies have been conducted to investigate the effects of …
35
Identification of genetic variants that influence bipolar I disorder (BPD-I) through genome-wide association (GWA) studies is limited in Asian populations. The current study …
36
Os antipsicóticos são fármacos usados no tratamento sintomático dos transtornos psiquiátricos nomeadamente na esquizofrenia, na fase maníaca do transtorno bipolar e em outras …
37
… patients treated with clozapine (n=239), olanzapine (n=70), or risperidone (n=170) for an average of 48.2+/-27.8 months, in singlemarker-based analysis, the DRD2 rs4436578-C …
38
… Patients on long term SGA treatment carrying the rs4436578-C/C genotype in the D2 receptor had a higher risk of more than 7% weight gain than patients with the C/T or T/T genotype (…
39
… , rs4436578, has an effect on DRD2 functioning and directly contributes to the underlying pathophysiology of AAP-associated BWG. For instance, the significant rs4436578 … rs4436578 …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.