Genetics Research
rs521018
Population Frequencies12
African
G 0.39081T 0.60919GG 0.264808GT/TG 0.252011TT 0.483182pop=34,075
African American
G 0.39116T 0.60884GG 0.265427GT/TG 0.251463TT 0.48311pop=32,805
African Others
G 0.3819T 0.6181GG 0.248819GT/TG 0.266142TT 0.485039pop=1,270
Asian
G 0.1383T 0.8617GG 0.079761GT/TG 0.117149TT 0.803091pop=4,012
East Asian
G 0.1304T 0.8696GG 0.075296GT/TG 0.110143TT 0.814561pop=3,214
European
G 0.351399T 0.648601GG 0.225831GT/TG 0.251172TT 0.522997pop=206,102
Latin American 1
G 0.3415T 0.6585GG 0.223597GT/TG 0.235396TT 0.541007pop=6,952
Latin American 2
G 0.40655T 0.59345GG 0.275696GT/TG 0.261777TT 0.462527pop=11,214
Other
G 0.3533T 0.6467GG 0.23124GT/TG 0.244257TT 0.524502pop=7,841
Other Asian
G 0.17T 0.83GG 0.097744GT/TG 0.145363TT 0.756892pop=798
South Asian
G 0.489T 0.511GG 0.412088GT/TG 0.153846TT 0.434066pop=364
Studies20
Unread Studies20 ▼
1
Serotonin (5-hydroxytryptamine; 5-HT) is a key neuromodulator involved in the regulation of mood, appetite, aggression, and impulse control. Dysregulation of central 5-HT function has …
2
… The rs498177 CC genotype was associated with an increased risk of MetS in women, and the rs521018–rs498177 haplotype was more frequent among individuals with MetS [43]. No …
3
… Thus, an association of the rs521018 polymorphism was identification of the gene HTR2C (5-hydroxytryptamine receptor 2C) with increased BMI in patients with schizophrenia but not …
4
Metabolic syndrome (MetS) is common among schizophrenia patients, and one of MetS’s causes may be an imbalance in nitric oxide regulation. In this study, we examined associations …
5
… frequencies were found for the polymorphic variant rs521018 of the HTR2C gene in the group of … , we could find a relationship between rs521018 of HTR2C and increased body weight. …
6
Patients with schizophrenia are characterized by high prevalence of obesity, smoking, substance use, cardiovascular disease, and suicidality with an approximately twice the …
7
… (rs1414334 proxy) rs498177, rs521018, rs5988072, rs2192371, rs12833104 … SCZ; n = 456 (299/157); Han Chinese the rs521018-rs498177 haplotype was significantly associated with …
8
Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how …
9
Clozapine is, and will remain in the coming years, an irreplaceable drug in psychiatry which has elective indication in treatment-resistant schizophrenia, suicide risk in schizophrenia …
10
… A study by Bai and coworkers revealed a gender-dependent association between rs521018 and … Moreover, the same study indicated that the A–C haplotype of rs521018–rs498177 …
11
Clozapine is quite effective to treat schizophrenia, but its use is complicated by several factors. Although many patients respond to antipsychotic therapy, about 50% of them …
12
Metodologia Celem niniejszej publikacji jest analiza udziału czynników genetycznych w indukowanym lekami przeciwpsychotycznymi (głównie drugiej generacji–atypowymi) przyroście …
13
Zaburzenia metaboliczne są szczególnie powszechne w populacji pacjentów otrzymujących leki przeciwpsychotyczne. W grupie tej częstość ich występowania wynosi ok. 50%. Ich …
14
… Haplotype analysis shows that the A–C type of rs521018–rs498177 in the HTR2C gene significantly decreased the risk of MetS (corrected p=0.0108) in female patients. CONCLUSIONS…
15
Objective Single nucleotide polymorphisms (SNPs) in serotonin related genes influence mental disorders, responses to pharmacological and psychotherapeutic treatments. In planning association studies, researchers that want to investigate new SNPs have to select some among a large number of candidates. Our aim is to guide researchers in the selection of the most likely phenotype affecting polymorphisms. Here, we studied serotonin receptor 2C (HTR2C) SNPs because, till now, only relatively few of about 2000 are investigated. Methods We used the most updated and assessed bioinformatic tools to predict which variations can give rise to biological effects among 2450 HTR2C SNPs. Results We suggest 48 SNPs that are worth considering in future association studies in the field of psychiatry, psychology and pharmacogenomics. Moreover, our analyses point out the biological level probably affected, such as transcription, splicing, miRNA regulation and protein structure, thus allowing to suggest future molecular investigations. Conclusions Although few association studies are available in literature, their results are in agreement with our predictions, showing that our selection methods can help to guide future association studies. Copyright © 2011 John Wiley & Sons, Ltd.
16
Eine klinisch relevante Gewichtszunahme stellt unter antipsychotischer Behandlung mit Substanzen der zweiten Generation, den atypischen Antipsychotika, eine häufige und …
17
HTR2C is one of the most relevant and investigated serotonin receptors. Its role in important brain structures such as the midbrain, the lateral septal complex, the hypothalamus, the …
18
… Haplotype analysis shows that the AC type of rs521018-rs498177 in the HTR2C gene significantly decreased the risk of MetS (corrected p = 0.0108) in female patients. …
19
… (rs521018, rs498207, … rs521018 and rs498207 were found to be in complete linkage disequilibrium (LD) (|D′| = 1 and r 2 = 1). However LD between SNP rs3813928 and rs521018 as …
20
To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence. Methods: We compared allele frequencies of five HTR2C …
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