Genetics Genetics Research
CHROMOSOME 11 FOLR2 11q13.4 GENE VIEW FOLR2 · 11q13.4 11q12 11q14 rs651933 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs651933 G / A · FOLR2 · 11q13.4 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ G 5′ 3′ G HETEROZYGOUS 5′ 3′ G 5′ 3′ A HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ A 5′ 3′ A G Guanine — reference allele A Adenine — variant allele genetics.jdge.cc

rs651933

Gene: FOLR2 — Folate Receptor Beta Chr 11:72215616 11q13.4 2KB upstream variant
NCBI ↗ Research Rabbit ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total G 0.530634A 0.469366GG 0.288158GA/AG 0.484953AA 0.226889pop=683,480 ↬
African G 0.30806A 0.69194GG 0.095953GA/AG 0.424215AA 0.479832pop=59,946
African American G 0.3107A 0.6893GG 0.097509GA/AG 0.426385AA 0.476107pop=57,882
African Others G 0.234A 0.766GG 0.052326GA/AG 0.363372AA 0.584302pop=2,064
Asian G 0.53612A 0.46388GG 0.3038GA/AG 0.464645AA 0.231556pop=11,738
East Asian G 0.5617A 0.4383GG 0.324503GA/AG 0.474471AA 0.201025pop=9,362
European G 0.55244A 0.44756GG 0.305835GA/AG 0.493211AA 0.200954pop=555,300
Latin American 1 G 0.512A 0.488GG 0.263006GA/AG 0.497936AA 0.239059pop=9,688
Latin American 2 G 0.65444A 0.34556GG 0.430312GA/AG 0.448261AA 0.121427pop=18,052
Other G 0.51429A 0.48571GG 0.272648GA/AG 0.483291AA 0.24406pop=20,708
Other Asian G 0.4352A 0.5648GG 0.222222GA/AG 0.425926AA 0.351852pop=2,376
South Asian G 0.4627A 0.5373GG 0.228628GA/AG 0.468191AA 0.303181pop=8,048

Studies2

Unread Studies2 ▼
1

Maternal arsenic exposure modifies associations between arsenic, folate and arsenic metabolism gene variants, and spina bifida risk: A case‒control study in …

Study ↗ PDF ↗
Spina bifida is a type of neural tube defect (NTD); NTDs are developmental malformations of the spinal cord that result from failure of neural tube closure during …

2024 · CF Wei, G Tindula, SK Mukherjee, X Wang…

2

Prenatal arsenic exposure, folic acid use and spina bifida in Bangladesh

Study ↗ PDF ↗
Spina bifida, a severe neural tube defect, constitutes a substantial population health burden globally. It increases the risk of stillbirth, infant and child mortality, and multiple neurological …

2024 · CF Wei

Curated Studies0 ▼

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0 ▼

No unused studies.