Genetics Genetics Research
CHROMOSOME X MAOA Xp11.3 GENE VIEW MAOA · Xp11.3 Xp12 Xp10 rs796065312 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs796065312 Arginine 45 → Tryptophan C / T · MAOA · Xp11.3 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ C 5′ 3′ C HETEROZYGOUS 5′ 3′ C 5′ 3′ T HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ T 5′ 3′ T C Cytosine — reference allele T Thymine — variant allele genetics.jdge.cc

rs796065312

Arginine 45 → Tryptophan Gene: MAOA — Monoamine Oxidase A Chr X:43683572 Xp11.3 Missense Variant
NCBI ↗ Research Rabbit ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ ClinVar ↗ Varsome ↗ LOVD ↗

Population Frequencies2

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Global C 0.999999T 0.000001pop=1,049,744 ↬
European C 0.999999T 0.000001pop=880,421

Studies2

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1

Genetic Variants Associated with Aggressive Behaviour in Humans: The Serotonergic System

Study ↗ PDF ↗
Human Aggressive Behaviour is not a simple characteristic to study and analyse. The molecular and biochemical mechanisms that regulate one’s behaviour are under the influence of multiple components, both genetic and environmental. Several recent association studies have compiled lists of candidate genes, polymorphisms and molecular pathways considered to be strong candidates for genetic factors partially responsible for some form of aggressive behaviour. The main goal of the project was to study some of these polymorphisms, in order to understand their evolution and current role in the human system. This study focused on variants in genes from the serotonergic system, that has consistently been associated with aggression.

2020 · PG Mariana de Leão

2

MAOA Gene Associated with Aggressive Behavior in Humans

Study ↗ PDF ↗
PID
The focus on behavioral genetics is primarily associated with destructive and anti-social behavioral activity and its findings are dispersed to the human beings. Behavioral genetics is multi-disciplinary, involving academic areas such as biology, genetics, psychology, social science and humanities. Monoamine oxidase is a mitochondrial enzyme involved in metabolism of various biological amines which are important neurotransmitters in the pathogenesis of major psychiatric disorders. In this review, the inheritance pattern and clinically significant polymorphisms of MAOA gene has been described. The results of abnormal behavior among human beings have stimulated research in understanding the relationship between metabolomic, genetic makeup which is surrounding with the environmental factors. The findings from behavioral research have ability to change the individual’s characters. Recent, research studies have documented that genetics may contribute for violent and anti-social behavior.

2017 · V Ramakrishnan, Akram Husain RS

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