Genetics Research
rs9606756
Population Frequencies12
African
A 0.84273G 0.15727AA 0.709759AG/GA 0.265933GG 0.024308pop=56,360
African American
A 0.84268G 0.15732AA 0.709675AG/GA 0.266017GG 0.024307pop=54,222
African Others
A 0.8438G 0.1562AA 0.71188AG/GA 0.263798GG 0.024322pop=2,138
Asian
A 0.97589G 0.02411AA 0.952638AG/GA 0.046512GG 0.000851pop=14,104
East Asian
A 0.97677G 0.02323AA 0.954486AG/GA 0.044578GG 0.000937pop=10,678
European
A 0.883131G 0.116869AA 0.779871AG/GA 0.20652GG 0.013609pop=607,398
Latin American 1
A 0.8685G 0.1315AA 0.755995AG/GA 0.224911GG 0.019094pop=9,008
Latin American 2
A 0.83395G 0.16605AA 0.69836AG/GA 0.271188GG 0.030451pop=18,784
Other
A 0.88635G 0.11365AA 0.786345AG/GA 0.200011GG 0.013644pop=36,938
Other Asian
A 0.9731G 0.0269AA 0.946877AG/GA 0.052539GG 0.000584pop=3,426
South Asian
A 0.9036G 0.0964AA 0.821321AG/GA 0.164567GG 0.014113pop=7,936
Studies66
Unread Studies66 ▼
1
The high prevalence of insulin resistance and metabolic syndrome in Kuwait increases the risk of type 2 diabetes (T2D) and cardiovascular diseases development. Although the genetic …
2
A disintegrin and metalloproteinase Domain 9 (ADAM9) is a zinc-dependent proteinase involved in various biological processes. However, its role in the pathophysiology of metabolic …
3
Hyperhomocysteinemia (HHcy), a condition characterized by elevated plasma levels of the sulfur‐containing amino acid homocysteine, has emerged as a multifactorial and systemic …
4
After the completion of the Human Genome Project in 2003, the impact of genetic variations among people on human health was better understood. Precision medicine, …
5
… Relationship between cobalt transporter II gene rs9606756 site mutant and serum homocysteine level and recurrent cerebral infarction in young and middle-aged people. Minerva …
6
… TCN2 rs9606756 polimorfizmi düşük B12 vitamini … 2 otizm hastası TCN2 (rs9606756-G) geninde heterozigot (AG), 4 otizm hastası ise TCN2 (rs1801198-G) geninde heterozigottur (CG). …
7
Dr. Dalia El Khoury Metabolic Syndrome (MetS) prevalence is high in Canada, prompting research into more effective biomarkers and interventions. Although studies suggest …
8
Overweight and obesity (OO) are significant public health issues, and many elements, including genetics, epigenetics, sedentary lifestyle, comorbid conditions, …
9
Frontiers | Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait Frontiers in …
10
The information shared between the brain and gastrointestinal system is the result of a multitude of unidirectional and bidirectional influencers. Bacteria appear to have a large influence …
11
The aim of this study was to assess the association of vitamin B12 level and single nucleotide polymorphisms (SNPs) in vitamin B12 metabolic genes with pulmonary tuberculosis (PTB) …
12
… examining the presence of putative single-nucleotide polymorphisms (SNPs) related to vitamin B 12 levels in patients with PA, which found out that a genetic variant of TCN2 (rs9606756…
13
This is the comprehensive guide to utilising nutrigenomics in clinical practice. A cutting-edge field, nutrigenomics examines the effects of foods on gene expression. From a …
14
Research question Are there genetic determinants shared by unrelated women with unexplained recurrent early miscarriage (REM)? Design Thirty REM cases and 30 controls were …
15
… Figure 14: A) MAF distribution of rs9606756 among the three subgroups of Kuwaiti Arab population; B and C) Interaction between WC vs. Apo-A1 and HDL-C, respectively, at three …
16
ぞれ 13.27 および 2.74 で, 発症と有意な相関があった. さらに, トランスコバラミン 2 遺伝子 (TCN2) 上の 2 つの SNP (rs9606756 および rs9621049) のヘテロ接合体の臍帯ヘルニア発症オッズ比は…
17
Mendelian randomisation (MR) designs apply instrumental variable techniques using genetic variants to study causal effects. MR is increasingly used to evaluate the role of …
18
Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an …
19
While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for metabolic traits. Determining the …
20
Obesity, one of the most common chronic health conditions worldwide, is a multifactorial disease caused by complex genetic and environmental interactions. Several …
21
Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and …
22
Przewlekłe powikłania cukrzycy są główną przyczyną obniżenia jakości życia, niepełnosprawności, a nawet przedwczesnej śmierci pacjentów cierpiących na tę chorobę. Mimo …
23
… of rs9606756 mutation in the recurrent group was higher than that in the non-recurrent group (P<0.05), and the Hcy level in rs9606756 … different genotypes of rs9606756 in the recurrent …
24
Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies on diabetes genetics. …
25
Association studies have implicated single nucleotide polymorphisms (SNPs), particularly rs1421085, from the fat mass and obesity-associated (FTO) gene with body composition …
26
Association studies have implicated single nucleotide polymorphisms (SNPs), particularly rs1421085, from the fat mass and obesity-associated (FTO) gene with body composition …
27
Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy. Transcobalamin II (TCN2) and transcobalamin receptor (TCblR) proteins …
28
Son yıllarda yapılan çalıĢmalarda toplumda B12 vitamini eksikliği yaygın olarak görülmektedir. B12 vitamin eksikliğine yol açan genetik faktörlerinde yer aldığı birçok faktör rol oynar. …
29
… The second polymorphism of that gene namely TCN2 67A> G (rs9606756) that causes Ile23Val substitution has been studied only in Brazilian population and did not find any …
30
Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an …
31
The association of mitochondrial DNA (mtDNA) variations with obesity has been investigated in diverse populations across the world. However, such obesity-associated …
32
Folate‐mediated one‐carbon metabolism ( FOCM ) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5…
33
Disturbances in one-carbon metabolism, intracellular reactions involved in nucleotide synthesis and methylation, likely increase the risk of colorectal cancer (CRC). However, results …
34
… In summary, our study suggests that TCN2(rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B 12 deficiency are correlated with risk of CD in Chinese …
35
Despite alarming obesity levels in the Arabian Peninsula, its population lacks convincingly identified genetic determinants of obesity. A genome‐wide association study was …
36
It has been reported that abnormal elevation of homocysteine is quite prevalent in ulcerative colitis (UC) patients. We attempted to explore the relationship of UC with transcobalamin II (…
37
… frequencies of rs1801198 and rs9606756 did not differ … for the G allele and AG genotype of rs9606756 (both P< 0.05). … for individuals with AA of rs9606756 when compared with those …
38
… The frequencies of mutant allele (G) and heterozygous genotype (AG) of rs9606756 were … The two polymorphic loci (rs1801198 and rs9606756) were shown to be in a weak linkage …
39
The clinical use of holotranscobalamin (holoTC) testing to evaluate vitamin B 12 status has increased in recent years. We present two patients (African Caribbean and …
40
Down syndrome (DS) originates, in most of the cases (95 %), from a full trisomy of chromosome 21. The remaining cases are due to either mosaicism for chromosome 21 or the …
41
Intracranial aneurysm (IA) is a vascular condition characterized as a saccular dilatation of the cerebral artery wall. The purpose of this study was to identify genetic variants that cause …
42
Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital deformity, often associated with folate deficiency. The genes MTHFR, MTR, MTRR, and TCN2 play …
43
Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions of …
44
Global decrease in DNA methylation is a common feature of cancer and is associated with genomic and chromosomal instability. Retrospective case–control studies have reported that …
45
Altered DNA methylation has been associated with various diseases. Objective: We evaluated the association between levels of methylation in leukocyte DNA at long …
46
Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-…
47
… The three SNPs with the strongest associations with LINE-1 methylation were all in TCN2, including two exonic SNPs that result in missense substitutions (rs9606756 and …
48
O aborto espontâneo recorrente (AER) é definido pela ocorrência de três ou mais abortos espontâneos consecutivos com idade gestacional de até 20 semanas. O AER é um evento …
49
… rs9606756 was not included in the set of SNPs genotyped at Kbioscience and was … As an indication of imputation quality, rs9606756 genotypes from imputation had an R 2 value …
50
Both taking folic acid-containing vitamins around conception and consuming food fortified with folic acid have been reported to reduce omphalocele rates. Genetic factors are …
51
Esta tese apresenta estudos realizados sobre as bases moleculares do metabolismo do ácido fólico (AF), da cobalamina (Cbl) e do ferro, os quais são micronutrientes essenciais na …
52
Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites …
53
Functional vitamin B12 (cobalamin) deficiency is a subtle, progressive clinical disorder affecting 6-23% of elderly adults. Its symptoms, including fatigue, mood disturbances, and …
54
Danish legislation regarding food fortification has been very restrictive resulting in few fortified food items on the Danish market. Folate and vitamin B12 deficiency is thought to be …
55
The evolutionary and biomedical importance of differential mRNA splicing is well established. Numerous studies have assessed patterns of differential splicing in different genes and …
56
Tra le malformazioni congenite in generale e quelle orofacciali in particolare, le schisi labiopalatine occupano un posto di primaria importanza, non soltanto per la frequenza elevata …
57
Folate metabolism plays a critical role in embryonic development. Prenatal folate supplementation reduces the risk of neural tube defects and probably oral facial clefts. Previous studies …
58
Cleft lip with or without cleft palate (CL/P) is the most common inborn craniofacial anomaly. Affected individuals require extensive medical and psychosocial support. Although CL/P has …
59
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a …
60
Catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-…
61
The "Developmental Origins of Health and Disease" hypothesis suggests that adverse environmental exposures during critical prenatal and early postnatal periods influence long-term …
62
Marker and sample sets. Quality control analyses resulted in a marker set of 632,375 SNPs (reduced down from 730,525), discovery cohort of 1,353 samples (reduced down …
63
The high prevalence of insulin resistance and metabolic syndrome in Kuwait increases the risk of type 2 diabetes (T2D) and cardiovascular diseases development. Although the genetic …
64
Our results show a significant negative correlation between SDI and total motile sperm count (TMSC) where SDI of less than 20%, 20 to 29.9% and more than 30% were …
65
Аутоиммунный гастрит (АИГ) представляет собой воспаление слизистой оболочки тела желудка с аутоиммунным механизмом развития, в результате которого развивается …
66
… The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesityrelated traits and mediates by interacting with Apo-A1. Obesity 25, 1098–1108. doi: 10.1002/oby.21826 …
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